| Long-term endocrine sequelae after surgery, radiotherapy, and chemotherapy in children with medulloblastoma. | |
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MedLine Citation:
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PMID: 3802038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirteen children with medulloblastoma, were studied after 2 to 62 months off radiotherapy and chemotherapy with methotrexate and BCNU. Ages at time of study ranged from 2.3 to 15.7 years. Eleven patients, followed for a mean of 22 months, showed a significant decrease of height score, whereas nine patients had deficient growth hormone (GH) response to provocative tests. Clinical pubertal progression was normal in all patients, and three of five girls with advanced pubertal development had menarche. No evidences of gonadotropin disturbances were found in five patients whereas seven had raised basal follicle-stimulating hormone (FSH) level or FSH response to luteinizing hormone-releasing hormone (LH-RH). Abnormalities in thyrotrophin (TSH) secretion were found in 9 of 13 patients. This study shows that poor growth and GH deficiency were frequent in our patients. The high frequency of thyroid disturbances observed point out the need of evaluating thyroid function for adequate replacement therapy. Perhaps modification of adjuvant chemotherapy in the future can diminish drug-induced gonadal damage. |
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Authors:
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T Pasqualini; B Diez; H Domene; M E Escobar; L Gruñeiro; J J Heinrich; A Martinez; S Iorcansky; F Sackmann-Muriel; M Rivarola |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 59 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-03-19 Completed Date: 1987-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 801-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Agents / adverse effects Brain Neoplasms / therapy* Child Child, Preschool Combined Modality Therapy Endocrine System Diseases / etiology* Female Gonads / physiology Growth Disorders / etiology Growth Hormone / analysis Humans Hypothalamo-Hypophyseal System / physiology Male Medulloblastoma / therapy* Radiotherapy / adverse effects Sex Differentiation Disorders / etiology Thyroid Diseases / etiology Thyroid Function Tests |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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