| Long-term efficacy of thalamic deep brain stimulation for tremor: double-blind assessments. | |
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MedLine Citation:
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PMID: 12539209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thalamic deep brain stimulation (DBS) is proven to suppress tremor in Parkinson's disease (PD) and essential tremor (ET). However, there are few reports on its long-term efficacy. We studied the efficacy of DBS at 2 years and 6-7 years after electrode implantations in the ventrointermediate nucleus of the thalamus in 39 patients (20 PD, 19 ET) with severe tremor. Twenty-five of the patients completed the study. Evaluations were done in a double-blind manner with the Unified Parkinson's Disease Rating Scale (UPDRS) and Essential Tremor Rating Scale (ETRS). DBS decreased tremor sum scores in PD (P < 0.025) compared to the preoperative baseline (median, 7; Q25-75, 6-9) both at 2 years (median, 2; Q25-75, 2-3.5; n = 16) and at 6 to 7 years (median, 2.5; Q25-75, 0.5-3; n = 12). Stimulation on improved tremor sum as well as sub scores (P < 0.025) compared to stimulation off conditions. In ET, thalamic stimulation improved (P < 0.025) kinetic and positional tremor at both follow-up periods (n = 18 and n = 13, respectively) with significant improvements (P < 0.025) in hand-function tests. PD but not ET patients showed a general disease progression. Stimulation parameters were remarkably stable over time. We conclude that high-frequency electric thalamic stimulation can efficiently suppress severe tremor in PD and ET more than 6 years after permanent implantation of brain electrodes. |
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Authors:
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Stig Rehncrona; Bo Johnels; Håkan Widner; Anna-Lena Törnqvist; Marwan Hariz; Olof Sydow |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 18 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-22 Completed Date: 2003-06-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Movement Disorder Society |
Affiliation:
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The Department of Clinical Neuroscience, Division of Neurosurgery, University in Lund, Sweden. stig.rehncrona@neurokir.lu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Double-Blind Method Electric Stimulation Therapy / methods* Essential Tremor / epidemiology, etiology, therapy* Female Follow-Up Studies Humans Male Observer Variation Parkinson Disease / complications Thalamus / physiology* Time |
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