Document Detail


Long-term efficacy and safety of polyacrylamide hydrogel injection in the treatment of human immunodeficiency virus-related facial lipoatrophy: a 5-year follow-up.
MedLine Citation:
PMID:  22186503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Facial lipoatrophy, a human immunodeficiency virus-related wasting of the facial soft tissues, can compromise patients' quality of life. Injection of different materials in the cheeks can improve this condition. Concern regarding potential long-term complications of nonbiodegradable fillers remains. The authors investigated the long-term efficacy and safety of polyacrylamide gel injections.
METHODS: Human immunodeficiency virus-infected patients treated with polyacrylamide gel for moderate to severe facial lipoatrophy with a minimum of 5 years' follow-up were included. Aquamid (1 ml) was injected monthly into each cheek until adequate correction was obtained. Outcome measures were ultrasound measurement of cheek soft-tissues thickness, evaluation of aesthetic improvement, and self-evaluation of satisfaction and psychological consequences of treatment (visual analogue scale for the face, Assessment of Body Change and Distress questionnaire, and Beck Depression Inventory score). Adverse events were classified as acute (<1 week), early (1 week to 1 month), midterm (1 month to 1 year), or late (>1 year).
RESULTS: One hundred forty-one patients completed the treatment as of June of 2005; 38 (32 men; mean age, 42 years) were available for follow-up of more than 5 years (mean, 62 months). The mean number of treatment sessions was seven over a mean period of 8 months. Significant improvement of cheek thickness and aesthetic result and highly significant satisfaction and psychological improvement were obtained. No serious adverse events occurred during the follow-up period.
CONCLUSION: The long-term efficacy and safety of polyacrylamide gel injection for the treatment of human immunodeficiency virus-related facial lipoatrophy were shown over a period of 5 years.
CLINICAL QUESTION/LEVEL OF EVIDENCE: : Therapeutic, IV.
Authors:
Giorgio De Santis; Marco Pignatti; Alessio Baccarani; Antonio Pedone; Antonio Spaggiari; Gabriella Orlando; Giovanni Guaraldi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  129     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-21     Completed Date:  2012-03-06     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acrylic Resins / administration & dosage*
Adult
Face
Female
HIV-Associated Lipodystrophy Syndrome / psychology,  therapy*
Humans
Hydrogels / administration & dosage*
Injections
Male
Middle Aged
Prostheses and Implants*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/Aquamid; 0/Hydrogels
Comments/Corrections
Comment In:
Plast Reconstr Surg. 2012 Jul;130(1):176e-177e; author reply 177e-178e   [PMID:  22743902 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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