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Long-term efficacy of psoriasis vulgaris treatments: Analysis of treatment with topical corticosteroid and/or vitamin D(3) analog, oral cyclosporin, etretinate and phototherapy over a 35-year period, 1975-2010.
MedLine Citation:
PMID:  23330814     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Various therapies have been tried for psoriasis. In Japan, biologics began to be used for psoriasis treatment in January 2010. Their clinical efficacy is well known, but biologics cannot be used in all psoriasis patients for reasons such as side-effects and cost. It is necessary to evaluate the effect of long-term psoriasis treatment, but there have been no reports evaluating long-term treatment. Therefore, the outcomes of patients who had been treated at the Tokai University Hospital for more than 5 years, before biological agents were released, were examined. Three categories, classified by initial severity, changes in severity by method of treatment and background characteristics, were investigated. In conclusion, cases of long-term treatment with a combination of topical corticosteroid and topical vitamin D(3) analog or oral cyclosporin were found to be effective therapies. Patients with a history of diabetes mellitus or cardiovascular disease of psoriasis were likely to be treatment resistant.
Authors:
Emiko Akasaka; Tomotaka Mabuchi; Yasuaki Manabe; Eiichiro Yahagi; Azusa Yamada-Hiruma; Hanako Yamaoka; Tomoko Kojima; Masayuki Kato; Norihiro Ikoma; Akira Ozawa; Yasuo Haruki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  The Journal of dermatology     Volume:  -     ISSN:  1346-8138     ISO Abbreviation:  J. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Japanese Dermatological Association.
Affiliation:
Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan.
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