Document Detail

Long-term efficacy of a fractional resurfacing device.
MedLine Citation:
PMID:  20166157     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Recently, there has been much debate regarding the long-term efficacy of fractional resurfacing devices. While pulsed CO(2) laser resurfacing is considered a highly effective treatment, fractionated resurfacing is a newer modality and its long-term efficacy has yet to be assessed. We report the long-term outcomes of subjects previously treated with fractional CO(2) resurfacing for photodamaged skin and acne scars. STUDY DESIGN/MATERIALS AND METHODS: Ten subjects from our previous studies who received fractional resurfacing for the treatment of acne scarring and photodamage returned for long-term follow-up visits at 1 and 2 years, respectively. Investigators graded maintenance of improvement on a quartile scale based on clinical photography. RESULTS: Subjects maintained 74% of their overall improvement at their long-term visits compared to 3-month follow-up visits. While clinical improvement was maintained long-term, the results were not as remarkable as those seen at 3-month visits. The authors speculate that results seen at 3 months may be enhanced by persistent inflammatory changes, as evidenced by heat shock protein 47 activity and ongoing collagen remodeling seen in previous histologic studies. Relaxation of tightening is to be expected with any procedure along with the natural progression of aging. However, patient satisfaction was upheld long-term. CONCLUSION: Fractional CO(2) laser resurfacing does have long-term efficacy and persistence of improvement of acne scarring and photodamage compared to baseline. However, additional treatments may be necessary to enhance long-term results.
Arisa E Ortiz; Anne Marie Tremaine; Christopher B Zachary
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  42     ISSN:  1096-9101     ISO Abbreviation:  Lasers Surg Med     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-26     Completed Date:  2010-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  168-70     Citation Subset:  IM    
Department of Dermatology, University of California at Irvine, Irvine, California 92697, USA.
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MeSH Terms
Acne Vulgaris / complications*,  diagnosis
Cicatrix / etiology,  surgery*
Cohort Studies
Follow-Up Studies
Laser Therapy / instrumentation*
Lasers, Gas / therapeutic use*
Middle Aged
Risk Assessment
Skin Aging
Time Factors
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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