Document Detail


Long-term efficacy of deferoxamine iron chelation therapy in adults with acquired transfusional iron overload.
MedLine Citation:
PMID:  3925909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transfusional iron overload in adult patients with acquired anemias may result in widespread organ dysfunction. Long-term deferoxamine mesylate therapy was administered by continuous subcutaneous infusion to six such patients, who have been followed up for up to 66 months of therapy while continuing to be transfusion-dependent. During deferoxamine therapy, liver density by computed tomographic scan decreased in four of five patients, liver iron content decreased in two of three patients, and liver function normalized in two patients. Plasma cortisol response to insulin-induced hypoglycemia improved in three of five patients receiving therapy. Pituitary growth hormone reserve normalized in two patients and remained normal in the other three tested. One patient, treated concurrently with ascorbic acid, died suddenly. The other five patients have had no cardiac deterioration by noninvasive testing. We conclude that long-term deferoxamine iron chelation therapy is effective not only in retarding but, in some cases, even reversing organ damage caused by transfusional iron overload.
Authors:
A I Schafer; S Rabinowe; M S Le Boff; K Bridges; R G Cheron; R Dluhy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  145     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-02     Completed Date:  1985-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1217-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / therapy
Blood Glucose
Blood Transfusion / adverse effects*
Deferoxamine / therapeutic use*
Glucose Tolerance Test
Hemosiderosis / drug therapy*,  etiology
Humans
Iron / metabolism*
Iron Chelating Agents / therapeutic use*
Liver Function Tests
Male
Middle Aged
Red-Cell Aplasia, Pure / therapy
Thyroid Function Tests
Grant Support
ID/Acronym/Agency:
MO1RR00888/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Iron Chelating Agents; 70-51-9/Deferoxamine; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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