| Long-term efficacy of anti-CD20 antibodies in refractory lupus nephritis. | |
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MedLine Citation:
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PMID: 21258801 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Eight patients with refractory lupus nephritis received rituximab after failing standard sequential therapy and were followed for 104 weeks after the infusion. One patient died secondary to a complicated pregnancy but had stable renal function. Three patients received a re-infusion of rituximab approximately 12 months apart due to a renal flare; during the second year of follow-up, those patients progressed toward ESRD. The four remaining patients demonstrated improvements in SLEDAI score, CrCl, and proteinuria with maintenance of their standard immunosuppressive therapy and did not require a re-infusion of rituximab. Although rituximab as induction therapy for refractory lupus nephritis has been shown to have a good response, its efficacy in long-term assessments demonstrates disappointing results. |
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Authors:
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C Alejandro Arce-Salinas; Felipe Rodríguez-García; J Iván Gómez-Vargas |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-22 |
Journal Detail:
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Title: Rheumatology international Volume: - ISSN: 1437-160X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Internal Medicine, Hospital Central Sur de PEMEX, Mexico city, Mexico, cesararces@yahoo.com. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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