Document Detail

Long-term effects of simvastatin in hypercholesterolemic patients with NIDDM and additional atherosclerotic risk factors. Hyogo Simvastatin Study Group.
MedLine Citation:
PMID:  7642176     Owner:  NLM     Status:  MEDLINE    
Effects of 12 months of simvastatin treatment were examined in 48 NIDDM patients with total serum cholesterol levels exceeding 220 mg/dl and were compared with those in 35 nondiabetic patients with hypercholesterolemia. In the diabetic group, 5-10 mg of simvastatin given once daily at bedtime significantly lowered total cholesterol (21%). LDL cholesterol (28%), apoB (15%) and triglycerides (8%) levels. These changes were identical to those in the nondiabetic group, except for triglycerides which did not change significantly. HDL cholesterol increased significantly in the nondiabetic group but not in the diabetic group. The reductions in LDL cholesterol and apoB in hypercholesterolemic patients with NIDDM were not influenced by gender, age, glycemic control, the presence or absence of systemic hypertension, obesity and overt proteinuria. In addition, the decrease in LDL cholesterol was not affected by the number of risk factors per patient. Simvastatin did not significantly alter hemoglobin A1c or fasting plasma glucose and was well tolerated in both groups. Simvastatin produced beneficial effects on serum lipids and apolipoproteins and neutral effects on glycemic control in hypercholesterolemic patients with NIDDM, whether or not they had an additional atherosclerotic risk factor.
T Kazumi; G Yoshino; A Ohki; K Matsuba; T Ino; M Amano; M Kasuga
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  27     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-21     Completed Date:  1995-09-21     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Department of Medicine, Hyogo Medical Center for Adults, Akashi, Japan.
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MeSH Terms
Anticholesteremic Agents / therapeutic use*
Arteriosclerosis / etiology*
Diabetes Mellitus, Type 2 / drug therapy*
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Hypercholesterolemia / drug therapy*
Lovastatin / analogs & derivatives*,  therapeutic use
Middle Aged
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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