Document Detail


Long-term effects of repetitive exposure to a static magnetic field (1.5 T) on proliferation of human fetal lung fibroblasts.
MedLine Citation:
PMID:  10204867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to assess the effects of repetitive exposures to a static magnetic field (1.5 T) on human fetal lung fibroblast (HFL) proliferation. HFL were exposed three times a week for 1 hr to a static magnetic field for 3 weeks. Cells were subcultured every week. Population doublings (PD) and cumulative population doublings (CPD) were calculated weekly. Colony formation assays, bromodeoxyuridine enzyme-linked immunosorbent assay, and cell cycle analysis were performed weekly. After the third week, proliferation kinetics were assessed. Over a period of 3 weeks no statistically significant differences between the PD and CPD of exposed and control cells could be detected. Clonogenic activity, DNA synthesis, cell cycle, and proliferation kinetics were not altered by magnetic field exposure. The data do not provide evidence that repetitive exposures to a static magnetic field (1.5 T) exert effects on HFL proliferation.
Authors:
J Wiskirchen; E F Groenewaeller; R Kehlbach; F Heinzelmann; M Wittau; H P Rodemann; C D Claussen; S H Duda
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  41     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-16     Completed Date:  1999-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  464-8     Citation Subset:  IM    
Affiliation:
Department of Radiology, Eberhard-Karls-Universität Tübingen, Germany. jakub.wiskirchen@uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Cell Division / radiation effects
Cells, Cultured / radiation effects
Electromagnetic Fields / adverse effects*
Fetus / radiation effects
Fibroblasts / cytology,  radiation effects*
Humans
Lung / anatomy & histology,  cytology,  embryology*
Magnetic Resonance Imaging / adverse effects*,  methods
Reference Values
Statistics, Nonparametric
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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