| Long-term effects on pressure and electromyography in a rat model of anal sphincter injury. | |
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MedLine Citation:
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PMID: 20628287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The goal of this research was to study the chronic effects of pudendal nerve transection and sphincterotomy on the anal sphincter, because there is no good animal model investigating anal sphincter injury. Clinically, anal sphincter dysfunction impacts a cohort of women who have fecal incontinence; conclusions from the study can benefit research for new effective treatments. METHODS: Sixty-eight virgin Sprague-Dawley rats were allocated into control (n = 12), sphincterotomy (n = 28), and pudendal nerve transection (n = 28) groups and were evaluated before injury and immediately, 4 days, 14 days, and 28 days after. Anal pressures and electromyography were recorded and statistically compared. The anal sphincter was submitted to histology. RESULTS:: Sphincterotomy data showed anal pressure recovery 14 days after injury and were comparable to controls after 28 days. Pudendal nerve transection showed a significant decrease in anal pressure 4 days after injury (P < .001), and this continued until 28 days after injury (P = .01). Electromyography showed significant loss of activity after nerve transection compared with controls. Twenty-eight days after sphincterotomy and nerve transection, fibrosis and muscle atrophy of the external anal sphincter muscle were demonstrated, respectively. CONCLUSION: Anal pressures recover significantly after sphincterotomy. Pudendal nerve transection caused atrophy of the external anal sphincter that was reflected by decreased pressures and electromyography. The results of this study can contribute to a better understanding of the mechanisms that lead to fecal incontinence and can be used to test the efficacy of therapies. |
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Authors:
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Levilester Salcedo; Margot Damaser; Robert Butler; Hai-Hong Jiang; Tracy Hull; Massarat Zutshi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 53 ISSN: 1530-0358 ISO Abbreviation: Dis. Colon Rectum Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: United States |
Other Details:
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Languages: eng Pagination: 1209-17 Citation Subset: IM |
Affiliation:
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Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anal Canal
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injuries,
pathology,
physiopathology* Animals Defecation Disease Models, Animal Electromyography* Fecal Incontinence / etiology, physiopathology* Female Fibrosis Follow-Up Studies Muscle, Smooth / pathology, physiopathology Pressure Rats Rats, Sprague-Dawley Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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