| Long-term effects of prepubertal testicular vessel ligation on testicular function in the rat. | |
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MedLine Citation:
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PMID: 2374222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of unilateral testicular vein and artery ligation in the immature rat on the function and final location of the testis at adulthood, 10-day-old male rats underwent either a sham operation or unilateral ligation of these vessels of the still undescended testis. Testicular location, blood flow, size and histology as well as ventral prostate weights were measured 50 days later at adulthood. At age 60 days, it was determined that all testes were descended into the scrotum, and there were no differences in testis and ventral prostate weights, intratesticular sperm counts and mean seminiferous tubular area between the control and sham operated animals. However, there was an 18% reduction in testicular blood flow (ml. per 100 gm. per minute +/- standard error of mean) in the operated animals when compared to the sham (20.43 +/- 1.10 versus 16.69 +/- 0.74, p less than 0.02). These data indicate that although there is a slight but significant reduction in testicular blood flow at adulthood when the testicular artery and vein are ligated early in life, this diminution is not sufficient to alter the ultimate location, testicular weight and spermatogenic function of the testis. This would suggest that after ligation of the main testicular vessels to the immature testis, the collateral blood supply is able to compensate with time to allow normal growth and development of the testis. These experimental observations provide additional support for the 2-staged approach to the high undescended testis whereby the testicular vessels are initially ligated and a subsequent procedure is performed to place the undescended testis into the scrotum. |
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Authors:
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J A Pascual; J Villanueva-Meyer; J L Rutgers; C A Lemmi; S C Sikka; R M Ehrlich; I Mena; J Rajfer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of urology Volume: 144 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-08-30 Completed Date: 1990-08-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 466-8; discussion 474 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance 90509. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Collateral Circulation Ligation Male Organ Size Prostate / pathology Rats Rats, Inbred Strains Regional Blood Flow Seminal Vesicles / pathology Seminiferous Tubules / pathology Sexual Maturation* Sperm Count Testis / blood supply*, pathology, physiology Vascular Surgical Procedures |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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