Document Detail

Long-term effects of porcine zonae pellucidae immunocontraception on ovarian function in feral horses (Equus caballus).
MedLine Citation:
PMID:  1317449     Owner:  NLM     Status:  MEDLINE    
Ten feral mares free-roaming in Maryland, USA, were inoculated with porcine zonae pellucidae (PZP) protein before the breeding season for three consecutive years (1988-90). Ovarian function was monitored for 51 days during the peak of the breeding season after the third annual PZP inoculation, in seven of these mares and in four untreated control mares, by means of urinary oestrone conjugates and nonspecific progesterone metabolites. None of the ten inoculated mares became pregnant in 1990, compared with 55% of 20 control mares, which included two of the four monitored for ovarian function. Three of the untreated mares demonstrated apparent normal ovarian activity, characterized by preovulatory oestrogen peaks, concurrent progesterone nadirs at ovulation, breeding activity, and luteal-phase progesterone increases after ovulation. Two of the seven monitored PZP-treated mares demonstrated ovulatory cycles that did not result in conception. One was pregnant as a result of conception in 1989 and demonstrated a normal, late-gestation, endocrine profile. The remaining four PZP-treated mares revealed no evidence of ovulation, and urinary oestrogen concentrations were significantly depressed. The experiments indicated that (i) a third consecutive annual PZP booster inoculation is greater than 90% effective in preventing pregnancies in mares and (ii) three consecutive years of PZP treatment may interfere with normal ovarian function as shown by markedly depressed oestrogen secretion.
J F Kirkpatrick; I M Liu; J W Turner; R Naugle; R Keiper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  94     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-07-02     Completed Date:  1992-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  437-44     Citation Subset:  IM    
Deaconess Research Institute, Billings, MT 59102.
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MeSH Terms
Contraception, Immunologic / veterinary*
Egg Proteins*
Estrogens, Conjugated (USP) / urine
Glycoproteins / pharmacology*
Horses / immunology,  physiology*
Membrane Glycoproteins*
Ovary / drug effects,  physiology*
Progesterone / metabolism
Receptors, Cell Surface*
Swine / immunology
Time Factors
Zona Pellucida / immunology*
Reg. No./Substance:
0/Egg Proteins; 0/Estrogens, Conjugated (USP); 0/Glycoproteins; 0/Membrane Glycoproteins; 0/Receptors, Cell Surface; 0/zona pellucida glycoproteins; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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