Document Detail

Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure.
MedLine Citation:
PMID:  17457340     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect on blood pressure of dietary advice to consume a combination of plant-based cholesterol-lowering foods (dietary portfolio). METHODS: For 1 year, 66 hyperlipidemic subjects were prescribed diets high in plant sterols (1.0 g/1000 kcal), soy protein (22.5 g/1000 kcal), viscous fibers (10 g/1000 kcal) and almonds (22.5 g/1000 kcal). There was no control group. Seven-day diet record, blood pressure and body weight were monitored initially monthly and later at 2-monthly intervals throughout the study. RESULTS: Fifty subjects completed the 1-year study. When the last observation was carried forward for non-completers (n=9) or those who changed their blood pressure medications (n=7), a small mean reduction was seen in body weight 0.7+/-0.3 kg (P=0.036). The corresponding reductions from baseline in systolic and diastolic blood pressure at 1 year (n=66 subjects) were -4.2+/-1.3 mm Hg (P=0.002) and -2.3+/-0.7 mm Hg (P=0.001), respectively. Blood pressure reductions occurred within the first 2 weeks, with stable blood pressures 6 weeks before and 4 weeks after starting the diet. Diastolic blood pressure reduction was significantly related to weight change (r=0.30, n=50, P=0.036). Only compliance with almond intake advice related to blood pressure reduction (systolic: r=-0.34, n=50, P=0.017; diastolic: r=-0.29, n=50, P=0.041). CONCLUSIONS: A dietary portfolio of plant-based cholesterol-lowering foods reduced blood pressure significantly, related to almond intake. The dietary portfolio approach of combining a range of cholesterol-lowering plant foods may benefit cardiovascular disease risk both by reducing serum lipids and also blood pressure.
D J A Jenkins; C W C Kendall; D A Faulkner; T Kemp; A Marchie; T H Nguyen; J M W Wong; R de Souza; A Emam; E Vidgen; E A Trautwein; K G Lapsley; R G Josse; L A Leiter; W Singer
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-04-25
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  62     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-05     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-8     Citation Subset:  IM    
Clinical Nutrition & Risk Factor Modification Center, St Michael's Hospital, Toronto, ON, Canada.
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MeSH Terms
Blood Pressure / physiology*
Body Weight / physiology*
Cholesterol / blood*
Cholesterol, Dietary / administration & dosage
Diet Records
Dietary Fiber / administration & dosage,  pharmacology
Hyperlipidemias / blood,  diet therapy*
Hypertension / diet therapy*,  etiology
Middle Aged
Obesity / diet therapy,  physiopathology
Phytosterols / administration & dosage,  pharmacology
Soybean Proteins / administration & dosage,  pharmacology
Weight Loss
Reg. No./Substance:
0/Cholesterol, Dietary; 0/Phytosterols; 0/Soybean Proteins; 57-88-5/Cholesterol

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