| Long-term effects of overfeeding during lactation on insulin secretion--the role of GLUT-2. | |
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MedLine Citation:
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PMID: 18708286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Overnutrition during critical developmental periods is believed to be a risk factor for the emergence of metabolic disorders in adulthood. The present study investigated the effects of pups overfeeding during lactation on offspring's insulin secretion. To study the consequences of overnutrition early in life in rats, litter size reduction has been shown to be an appropriate experimental model. To induce early postnatal overnutrition, litter size was reduced to three pups per litter at the third day following birth [overfed group (OG)]. In the control group (CG), the litter size was adjusted to 10 pups per litter. Metabolic parameters and glucose-stimulated insulin secretion were assessed. OG pups ingested more milk at 10 and 21 days and had an augmented food intake at 1 year compared to the CG. Consistently, body weight, body fat, and fasting plasma levels of insulin were higher in 1-year-old OG rats. In addition, OG rats exhibited enhanced insulin secretion, accompanied by elevated content of GLUT-2 in pancreatic islets compared to CG. These findings indicate that early postnatal overnutrition during a critical developmental period in life may program permanent alterations in glucose-stimulated insulin secretion. |
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Authors:
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Alessandra Cordeiro de Souza Rodrigues Cunha; Renata Oliveira Pereira; Mario José dos Santos Pereira; Vivian de Melo Soares; Mariana Renovato Martins; Michelle Teixeira Teixeira; Erica Patrícia Garcia Souza; Anibal Sanchez Moura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-15 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 20 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-10-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 435-42 Citation Subset: IM |
Affiliation:
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Departament of Physiological Sciences, State University of Rio de Janeiro, 20550-030 Rio de Janeiro, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Suckling Body Composition Body Weight Eating / physiology Female Glucose Transporter Type 2 / metabolism* Hyperphagia / metabolism* Insulin / secretion* Insulin-Secreting Cells / metabolism Lactation / physiology* Litter Size Proto-Oncogene Proteins c-akt Rats Rats, Wistar Time |
| Chemical | |
Reg. No./Substance:
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0/Glucose Transporter Type 2; 0/Slc2a2 protein, rat; 11061-68-0/Insulin; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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