Document Detail

Long-term effects of neonatal sodium restriction on blood pressure.
MedLine Citation:
PMID:  9095076     Owner:  NLM     Status:  MEDLINE    
In 1980, a randomized trial was conducted among 476 Dutch newborn infants to study the effect of a low or normal sodium diet on blood pressure during the first 6 months of life. At the end of the trial, systolic blood pressure in the low sodium group (n = 231) was 2.1 mm Hg lower than in the control group (n = 245). To investigate whether contrasting levels of sodium intake in infancy are associated with blood pressure differences in adolescence, we measured blood pressure in 167 children from the original cohort (35%) after 15 years of follow-up. We assessed the differences in systolic and diastolic blood pressure levels between the diet groups using a multivariate regression model with adjustment for potential confounders. The adjusted systolic blood pressure at follow-up was 3.6 mm Hg lower (95% confidence interval, -6.6 to -0.5) and the diastolic pressure was 2.2 mm Hg lower (95% confidence interval, -4.5 to 0.2) in children who had been assigned to the low sodium group (n = 71) compared with the control group (n = 96). These findings suggest that sodium intake in infancy may be important in relation to blood pressure later in life.
J M Geleijnse; A Hofman; J C Witteman; A A Hazebroek; H A Valkenburg; D E Grobbee
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  29     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  913-7     Citation Subset:  IM    
Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
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MeSH Terms
Age Factors
Blood Pressure*
Follow-Up Studies
Infant Nutritional Physiological Phenomena*
Infant, Newborn*
Multivariate Analysis
Regression Analysis
Sex Factors
Sodium, Dietary*
Time Factors
Reg. No./Substance:
0/Sodium, Dietary
Erratum In:
Hypertension 1997 May;29(5):1211

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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