Document Detail

Long-term effects of n-3 polyunsaturated fatty acids on haemostatic variables and bleeding episodes in patients with coronary artery disease.
MedLine Citation:
PMID:  7795149     Owner:  NLM     Status:  MEDLINE    
The long-term effects of fish-oil supplementation on haemostatic parameters and bleeding episodes were investigated in patients undergoing coronary artery bypass surgery. They were investigated before and 9 months after the operation. Following randomization postoperatively, 260 patients received 4 g fish-oil concentrate per day, whereas 251 patients comprised the control group. All patients received either aspirin (300 mg/day) or warfarin (international normalized ratio aimed at 2.5-4.2). Compliance was affirmed by determination of serum phospholipid fatty acids. No excess of bleeding episodes could be attributed to the use of fish oil, given in addition to either aspirin or warfarin. The supplementation of fish oil did not affect the bleeding time or plasma levels of beta-thromboglobulin, whereas an increase in the platelet count after the operation was slightly less pronounced in the fish-oil group. Apart from a small increase in PAI-1 antigen of borderline significance, no long-term effects by fish oil on parameters of coagulation and fibrinolysis were seen.
J Eritsland; H Arnesen; I Seljeflot; P Kierulf
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  6     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-07-31     Completed Date:  1995-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Department of Cardiology, Ullevål University Hospital, Oslo, Norway.
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MeSH Terms
Antithrombin III / analysis
Arteriosclerosis / epidemiology
Aspirin / administration & dosage,  adverse effects,  therapeutic use
Bleeding Time
Coronary Artery Bypass
Coronary Disease / blood,  drug therapy*,  surgery
Drug Therapy, Combination
Fatty Acids / blood
Fibrin Fibrinogen Degradation Products / analysis
Fish Oils / administration & dosage,  adverse effects,  therapeutic use*
Hemorrhage / chemically induced*
Hemostasis / drug effects*
Middle Aged
Peptide Hydrolases / analysis
Phospholipids / blood
Platelet Count
Risk Factors
Treatment Outcome
Triglycerides / blood
Warfarin / administration & dosage,  adverse effects,  therapeutic use
Reg. No./Substance:
0/Fatty Acids; 0/Fibrin Fibrinogen Degradation Products; 0/Fish Oils; 0/Phospholipids; 0/Triglycerides; 0/antithrombin III-protease complex; 50-78-2/Aspirin; 81-81-2/Warfarin; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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