Document Detail

Long-term effects of lipase inhibition by orlistat on gastric emptying and orocecal transit time of a solid meal.
MedLine Citation:
PMID:  18709483     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We assessed the impact of a prolonged lipase inhibition upon gastric emptying (GE) and orocecal transit time (OCTT) of a 355-kcal low-fat solid meal. METHODS: In double-blind manner, 40 obese women BMI > 30 kg/m2, randomly allocated into two equal groups, took orally t.i.d. 120 mg orlistat or placebo during 8 weeks of a weight-reducing management. At randomization and after 2 months, GE was measured simultaneously with OCTT by means of a 13C-octanoic acid and a hydrogen breath test, respectively. Lipolytic activity was evaluated with a 13C-mixed triglyceride breath test (13C-MTGBT). RESULTS: A profound lipase inhibition by orlistat was confirmed by a 79.5% +/- 16.9% reduction of the cumulative 6-h 13C recovery with 13CMTGBT. GE remained unchanged either in the orlistat (T1/2, 188 +/- 35 min start versus 198 +/- 36 min end) or the placebo (T1/2, 191 +/- 35 min start versus 180 +/- 39 min end) group. OCTT increased from 208 +/- 54 min to 271 +/- 64 min (P < 0.01) after orlistat treatment and did not change significantly (216 +/- 76 vs. 234 +/- 72 min) in the placebo group. CONCLUSIONS: No adverse effect on the GE and a moderate prolongation of the OCTT of a low-fat solid meal is to be expected under a prolonged treatment with orlistat at a typical dosage regimen.
Piotr Kocełak; Barbara Zahorska-Markiewicz; Krzysztof Jonderko; Magdalena Olszanecka-Glinianowicz; Agnieszka Zak-Gołab; Michał Holecki; Magdalena Kamińska; Małgorzata Szymszal
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-08-17
Journal Detail:
Title:  Journal of gastroenterology     Volume:  43     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  609-17     Citation Subset:  IM    
Department of Pathophysiology, Medical University of Silesia, 18 Medyków Street, Katowice, 40-752, Poland.
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MeSH Terms
Administration, Oral
Anti-Obesity Agents / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Follow-Up Studies
Gastric Emptying / drug effects*
Gastrointestinal Transit / drug effects*,  physiology
Jejunum / enzymology
Lactones / administration & dosage,  therapeutic use*
Lipase / antagonists & inhibitors*
Obesity / drug therapy*,  enzymology,  physiopathology
Prospective Studies
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Lactones; 96829-58-2/orlistat; EC

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