| Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure. | |
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MedLine Citation:
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PMID: 16713737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The calcium sensitizer levosimendan improves myocardial contractility in patients with heart failure, although its effects on inflammation and apoptosis are unknown. AIM: To examine the effects of levosimendan on markers of inflammation and apoptosis, over a period of 30 d following a 24 h infusion, in patients with heart failure. METHODS: Thirty four patients with severe heart failure were randomised to receive a 24 h infusion of levosimendan or placebo, in a double-blind trial. Haemodynamic evaluation and blood sampling were performed at baseline, 24 h, 30 h, 48 h, 7 d and 30 d after the end of the infusion. RESULTS: Seven patients (1 levosimendan, 6 placebo), were excluded during follow-up. In the remaining 27 patients, levosimendan decreased serum IL-6 and sFAS, 24 h after the infusion (p<0.01 and p<0.05 vs baseline), an effect sustained for 7-30 d. Serum TNF-alpha and sTNF-R1 were decreased between 48 h (p<0.01 vs baseline for both) and 7 d (p<0.05 vs baseline for sTNF-R1) after infusion. Serum sTNF-R2 was decreased at 24 h (p<0.05 vs baseline) and remained lower than baseline for at least 7 d (p<0.05). CONCLUSIONS: These findings indicate that levosimendan decreases the expression of proinflammatory cytokines, TNF-alpha receptors and sFAS, immediately after infusion, an effect which persists for 7-30 d. |
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Authors:
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Athanasios Trikas; Charalambos Antoniades; Giorgos Latsios; Karmen Vasiliadou; Ioannis Karamitros; Dimitris Tousoulis; Costantinos Tentolouris; Christodoulos Stefanadis |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2006-05-19 |
Journal Detail:
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Title: European journal of heart failure Volume: 8 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-02-21 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 804-9 Citation Subset: IM |
Affiliation:
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Athens University Medical School, A' Cardiology Department, Athens, Greece. atrikas@otenet.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD95 / metabolism* Female Heart Failure / drug therapy*, metabolism*, pathology Humans Hydrazones / administration & dosage, pharmacology*, therapeutic use* Inflammation / drug therapy, metabolism, pathology Infusions, Parenteral Interleukin-6 / blood Male Pyridazines / administration & dosage, pharmacology*, therapeutic use* Receptors, Tumor Necrosis Factor, Type I / metabolism Solubility Time Factors Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Hydrazones; 0/Interleukin-6; 0/Pyridazines; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Tumor Necrosis Factor-alpha; 131741-08-7/simendan |
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