Document Detail

Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure.
MedLine Citation:
PMID:  16713737     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The calcium sensitizer levosimendan improves myocardial contractility in patients with heart failure, although its effects on inflammation and apoptosis are unknown.
AIM: To examine the effects of levosimendan on markers of inflammation and apoptosis, over a period of 30 d following a 24 h infusion, in patients with heart failure.
METHODS: Thirty four patients with severe heart failure were randomised to receive a 24 h infusion of levosimendan or placebo, in a double-blind trial. Haemodynamic evaluation and blood sampling were performed at baseline, 24 h, 30 h, 48 h, 7 d and 30 d after the end of the infusion.
RESULTS: Seven patients (1 levosimendan, 6 placebo), were excluded during follow-up. In the remaining 27 patients, levosimendan decreased serum IL-6 and sFAS, 24 h after the infusion (p<0.01 and p<0.05 vs baseline), an effect sustained for 7-30 d. Serum TNF-alpha and sTNF-R1 were decreased between 48 h (p<0.01 vs baseline for both) and 7 d (p<0.05 vs baseline for sTNF-R1) after infusion. Serum sTNF-R2 was decreased at 24 h (p<0.05 vs baseline) and remained lower than baseline for at least 7 d (p<0.05).
CONCLUSIONS: These findings indicate that levosimendan decreases the expression of proinflammatory cytokines, TNF-alpha receptors and sFAS, immediately after infusion, an effect which persists for 7-30 d.
Athanasios Trikas; Charalambos Antoniades; Giorgos Latsios; Karmen Vasiliadou; Ioannis Karamitros; Dimitris Tousoulis; Costantinos Tentolouris; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-05-19
Journal Detail:
Title:  European journal of heart failure     Volume:  8     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-02-21     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  804-9     Citation Subset:  IM    
Athens University Medical School, A' Cardiology Department, Athens, Greece.
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MeSH Terms
Antigens, CD95 / metabolism*
Heart Failure / drug therapy*,  metabolism*,  pathology
Hydrazones / administration & dosage,  pharmacology*,  therapeutic use*
Inflammation / drug therapy,  metabolism,  pathology
Infusions, Parenteral
Interleukin-6 / blood
Pyridazines / administration & dosage,  pharmacology*,  therapeutic use*
Receptors, Tumor Necrosis Factor, Type I / metabolism
Time Factors
Tumor Necrosis Factor-alpha / blood
Reg. No./Substance:
0/Antigens, CD95; 0/Hydrazones; 0/Interleukin-6; 0/Pyridazines; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Tumor Necrosis Factor-alpha; 131741-08-7/simendan

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