| Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens. | |
MedLine Citation:
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PMID: 16422773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The long-term effects of supplementing Leghorn-type chickens with dietary L-carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell-mediated immune responses were assessed in a 12-week study. A commercial starter feed supplemented with 0 (control), 100 (LC) or 1,000 (HC) mg L-carnitine/kg was offered to day-old ISA Brown cockerels for 4 weeks, then all birds were given a commercial pullet grower feed for another 8 weeks. No differences (p > 0.05) in growth rates, feed intake or feed utilisation efficiency existed among the dietary treatments throughout the study. Compared with control birds, HC-fed birds had a lower (p < 0.05) thymus weight relative to bodyweight (BW) at Week 4, but a higher (p < 0.05) relative thymus weight at Week 12. A higher (p < 0.05) serum primary antibody response to sheep red blood cells (SRBC) in HC-fed birds than in the other two groups was also detected at Week 12. Relative spleen or bursa weights and cutaneous responses of toe webs to phytohaemagglutimin (PHA) (an in vivo indicator of cell-mediated immune responses) did not differ (p > 0.05) among dietary treatments at any time. It is concluded that a short-term supply of dietary L-carnitine to a conventional commercial feed after hatching enhanced subsequent humoral immunity in Leghorn-type chickens. Further study is warranted to confirm such a long-term effect. |
Authors:
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K Deng; C W Wong; J V Nolan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of animal physiology and animal nutrition Volume: 90 ISSN: 0931-2439 ISO Abbreviation: J Anim Physiol Anim Nutr (Berl) Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-20 Completed Date: 2006-05-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101126979 Medline TA: J Anim Physiol Anim Nutr (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 81-6 Citation Subset: IM |
Affiliation:
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Animal Science, School of Rural Science and Agriculture, University of New England, Armidale, NSW 2351, Australia. kdeng@jsu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed Animal Nutritional Physiological Phenomena Animals Antibody Formation / drug effects*, physiology Bursa of Fabricius / drug effects, physiology Carnitine / administration & dosage* Chickens / growth & development*, immunology* Dose-Response Relationship, Drug Immunity, Cellular / drug effects, physiology Organ Size / drug effects Phytohemagglutinins / immunology Random Allocation Spleen / drug effects, physiology Thymus Gland / drug effects, physiology Time Factors Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Phytohemagglutinins; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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