Document Detail

Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens.
MedLine Citation:
PMID:  16422773     Owner:  NLM     Status:  MEDLINE    
The long-term effects of supplementing Leghorn-type chickens with dietary L-carnitine after hatching for 4 weeks on growth, lymphoid organ weights, humoral and cell-mediated immune responses were assessed in a 12-week study. A commercial starter feed supplemented with 0 (control), 100 (LC) or 1,000 (HC) mg L-carnitine/kg was offered to day-old ISA Brown cockerels for 4 weeks, then all birds were given a commercial pullet grower feed for another 8 weeks. No differences (p > 0.05) in growth rates, feed intake or feed utilisation efficiency existed among the dietary treatments throughout the study. Compared with control birds, HC-fed birds had a lower (p < 0.05) thymus weight relative to bodyweight (BW) at Week 4, but a higher (p < 0.05) relative thymus weight at Week 12. A higher (p < 0.05) serum primary antibody response to sheep red blood cells (SRBC) in HC-fed birds than in the other two groups was also detected at Week 12. Relative spleen or bursa weights and cutaneous responses of toe webs to phytohaemagglutimin (PHA) (an in vivo indicator of cell-mediated immune responses) did not differ (p > 0.05) among dietary treatments at any time. It is concluded that a short-term supply of dietary L-carnitine to a conventional commercial feed after hatching enhanced subsequent humoral immunity in Leghorn-type chickens. Further study is warranted to confirm such a long-term effect.
K Deng; C W Wong; J V Nolan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal physiology and animal nutrition     Volume:  90     ISSN:  0931-2439     ISO Abbreviation:  J Anim Physiol Anim Nutr (Berl)     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-20     Completed Date:  2006-05-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101126979     Medline TA:  J Anim Physiol Anim Nutr (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Animal Science, School of Rural Science and Agriculture, University of New England, Armidale, NSW 2351, Australia.
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MeSH Terms
Animal Feed
Animal Nutritional Physiological Phenomena
Antibody Formation / drug effects*,  physiology
Bursa of Fabricius / drug effects,  physiology
Carnitine / administration & dosage*
Chickens / growth & development*,  immunology*
Dose-Response Relationship, Drug
Immunity, Cellular / drug effects,  physiology
Organ Size / drug effects
Phytohemagglutinins / immunology
Random Allocation
Spleen / drug effects,  physiology
Thymus Gland / drug effects,  physiology
Time Factors
Weight Gain
Reg. No./Substance:
0/Phytohemagglutinins; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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