Document Detail

Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.
MedLine Citation:
PMID:  2997286     Owner:  NLM     Status:  MEDLINE    
We studied the incorporation and metabolism of eicosapentanoic (EPA) and docosahexaenoic acid in six human volunteers who supplemented their normal Western diet for 5 mo daily with 10-40 ml of cod liver oil, rich in omega-3 polyunsaturated fatty acids. EPA and docosahexaenoic acid were incorporated into the total phospholipids of plasma, platelets, and erythrocytes in a dose- and time-dependent manner. During omega-3 fatty acid ingestion serum triacylglycerols were lowered and platelet aggregation upon low doses of collagen was reduced. Concomitantly, formation and excretion of prostanoids showed a characteristic change. As measured in serum from whole clotted blood, thromboxane A3 was formed in small amounts, whereas thromboxane A2 formation was reduced to 50% of control values. Excretion of the main urinary thromboxane A metabolites was unaltered in subjects with low basal excretion rates, but decreased markedly in two subjects with high control values. As determined from the main urinary metabolite, prostaglandin I3 was formed from EPA at rates up to 50% of unaltered prostaglandin I2 formation. The biochemical and functional changes observed lasted for the entire supplementation period of 5 mo and were reversible within 12 wk after cessation of cod liver oil intake. Favorable changes induced by long-chain omega-3 fatty acids include a dose-related and sustained shift of the prostaglandin I/thromboxane A balance to a more antiaggregatory and vasodilatory state.
C von Schacky; S Fischer; P C Weber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  76     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-27     Completed Date:  1985-11-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1626-31     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Blood Platelets / analysis
Cod Liver Oil / administration & dosage
Docosahexaenoic Acids
Eicosapentaenoic Acid / administration & dosage,  pharmacology*
Epoprostenol / biosynthesis*
Erythrocytes / analysis
Fatty Acids, Unsaturated / administration & dosage,  pharmacology*
Lipids / blood*
Platelet Aggregation / drug effects*
Thromboxane A2 / biosynthesis*
Thromboxane B2 / urine
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Lipids; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 35121-78-9/Epoprostenol; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2; 68794-57-0/prostaglandin I3; 8001-69-2/Cod Liver Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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