Document Detail

Long-term effects of dextrose prolotherapy for anterior cruciate ligament laxity.
MedLine Citation:
PMID:  12776476     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Use of dextrose prolotherapy. Prolotherapy is defined as injection that causes growth of normal cells or tissue. OBJECTIVE: Determine the 1 and 3 year efficacy of dextrose injection prolotherapy on anterior cruciate ligament (ACL) laxity. After year 1, determine patient tolerance of a stronger dextrose concentration (25% versus 10%). DESIGN: Prospective consecutive patient trial. SETTING: Outpatient physical medicine clinic. PATIENTS OR OTHER PARTICIPANTS: Eighteen patients with 6 months or more of knee pain plus ACL knee laxity. This laxity was defined by a KT1000 anterior displacement difference (ADD) of 2 mm or more. INTERVENTION: Intraarticular injection of 6-9 cc of 10% dextrose at months 0, 2, 4, 6, and 10. Injection with 6 cc of 25% dextrose at 12 months. Then, depending on patient preference, injection of either 10% or 25% dextrose every 2-4 months (based on patient preference) through 36 months. MAIN OUTCOME MEASURES: Visual analogue scale (VAS) for pain at rest, pain on level surfaces, pain on stairs, and swelling. Goniometric flexion range of motion, and KT1000-measured ADD were also measured. All measurements were obtained at 0, 6, 12 and 36 months. RESULTS: Two patients did not reach 6 month data collection, 1 of whom was diagnosed with disseminated cancer. The second was wheelchair-bound and found long-distance travel to the clinic problematic. Sixteen subjects were available for data analysis. KT1000 ADD, measurement indicated that 6 knees measured as normal (not loose) after 6 months, 9 measured as normal after 1 year (6 injections), and 10 measured as normal at 3 years. At the 3 year follow-up, pain at rest, pain with walking, and pain with stair use had improved by 45%, 43%, and 35% respectively. Individual paired t tests indicated subjective swelling improved 63% (P = .017), flexion range of motion improved by 10.5 degrees (P = .002), and KT1000 ADD improved by 71% (P = .002). Eleven out of 16 patients preferred 10% dextrose injection. CONCLUSION: In patients with symptomatic anterior cruciate ligament laxity, intermittent dextrose injection resulted in clinically and statistically significant improvement in ACL laxity, pain, swelling, and knee range of motion.
K Dean Reeves; Khatab M Hassanein
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Alternative therapies in health and medicine     Volume:  9     ISSN:  1078-6791     ISO Abbreviation:  Altern Ther Health Med     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-06-02     Completed Date:  2003-07-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9502013     Medline TA:  Altern Ther Health Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-62     Citation Subset:  IM    
Department of Biometry, University of Kansas Medical Center, Kansas City, Kan., USA.
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MeSH Terms
Anterior Cruciate Ligament / physiopathology*
Follow-Up Studies
Glucose / administration & dosage*
Growth Substances / administration & dosage*
Homeopathy* / methods
Injections, Intra-Articular
Joint Instability / drug therapy*,  physiopathology,  prevention & control
Middle Aged
Osteoarthritis, Knee / drug therapy*,  physiopathology
Pain Measurement
Prospective Studies
Severity of Illness Index
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Growth Substances; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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