| Long-term effects on cardiac output and peripheral resistance in patients treated with enalapril after acute myocardial infarction. CONSENSUS II Multi-Echo Study Group. Cooperative New Scandinavian Enalapril Survival Study. | |
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MedLine Citation:
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PMID: 9643277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the Cooperative New Scandinavian Enalapril Survival Study (CONSENSUS II), in which enalapril treatment was initiated intravenously within 24 h after acute myocardial infarction, there was a neutral effect on 6-month mortality, whereas a beneficial effect on the progression of congestive heart failure was noted. We studied the effect of enalapril on left ventricular systolic function in terms of cardiac output and mean acceleration time measured by pulsed-wave Doppler in the left ventricular outflow tract and peripheral resistance. Early angiotensin-converting enzyme inhibition after acute myocardial infarction did not result in a general improvement of cardiac output. However, a small increase in cardiac output was observed in a subgroup of enalapril-treated patients with ejection fraction > or = 45%, probably due to a reduction in peripheral resistance in these patients. |
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Authors:
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M Edner; K Caidahl; V V Bonarjee; D W Nilsen; S Carstensen; J Berning |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiology Volume: 89 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-09-22 Completed Date: 1998-09-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 291-6 Citation Subset: IM |
Affiliation:
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Division of Internal Medicine, Danderyds Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Blood Pressure / drug effects Cardiac Output / drug effects* Chi-Square Distribution Clinical Trials, Phase II as Topic Echocardiography, Doppler, Pulsed Enalapril / therapeutic use* Female Heart Rate / drug effects Humans Male Middle Aged Myocardial Infarction / complications, drug therapy*, physiopathology Prospective Studies Scandinavia Statistics, Nonparametric Vascular Resistance / drug effects* Ventricular Dysfunction, Left / drug therapy, etiology, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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