Document Detail

Long-term effects on cardiac output and peripheral resistance in patients treated with enalapril after acute myocardial infarction. CONSENSUS II Multi-Echo Study Group. Cooperative New Scandinavian Enalapril Survival Study.
MedLine Citation:
PMID:  9643277     Owner:  NLM     Status:  MEDLINE    
In the Cooperative New Scandinavian Enalapril Survival Study (CONSENSUS II), in which enalapril treatment was initiated intravenously within 24 h after acute myocardial infarction, there was a neutral effect on 6-month mortality, whereas a beneficial effect on the progression of congestive heart failure was noted. We studied the effect of enalapril on left ventricular systolic function in terms of cardiac output and mean acceleration time measured by pulsed-wave Doppler in the left ventricular outflow tract and peripheral resistance. Early angiotensin-converting enzyme inhibition after acute myocardial infarction did not result in a general improvement of cardiac output. However, a small increase in cardiac output was observed in a subgroup of enalapril-treated patients with ejection fraction > or = 45%, probably due to a reduction in peripheral resistance in these patients.
M Edner; K Caidahl; V V Bonarjee; D W Nilsen; S Carstensen; J Berning
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiology     Volume:  89     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-09-22     Completed Date:  1998-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Division of Internal Medicine, Danderyds Hospital, Sweden.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure / drug effects
Cardiac Output / drug effects*
Chi-Square Distribution
Clinical Trials, Phase II as Topic
Echocardiography, Doppler, Pulsed
Enalapril / therapeutic use*
Heart Rate / drug effects
Middle Aged
Myocardial Infarction / complications,  drug therapy*,  physiopathology
Prospective Studies
Statistics, Nonparametric
Vascular Resistance / drug effects*
Ventricular Dysfunction, Left / drug therapy,  etiology,  ultrasonography
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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