| Long-term effects of captopril in hypertension. | |
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MedLine Citation:
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PMID: 6996895 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Captopril was given for treatment of hypertension alone or in combination with diuretics to 32 patients for 1- to 4-mo periods. The decrement of mean blood pressure after 1 and 2 mo correlated with pretreatment plasma renin activity (PRA) and the response of blood pressure to infusion of an angiotensin II antagonist. These correlations were no longer apparent after 4 mo of treatment. When subjects with a decrement of mean blood pressure that exceeded 13 mm Hg were compared with nonresponders, responders not only had higher control PRA and higher PRA at 1 mo of treatment, but also had decreased plasma aldosterone levels, decreased urinary aldosterone excretion, and increased serum postassium levels that persisted over the 4 mo of observation. The reduction of plasma aldosterone correlated with the fall of mean blood pressure. Urinary kallikrein, catecholamines, electrolytes, and endogenous creatinine clearance did not change in response to treatment. These findings indicate that the antihypertenisve activity of captopril on long-term administration probably depends in part on the blockade of angiotensin II, but other mechanisms cannot be excluded. |
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Authors:
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A Maruyama; T Ogihara; T Naka; H Mikami; T Hata; M Nakamaru; K Iwanaga; Y Kumahara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 28 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1980-11-20 Completed Date: 1980-11-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 316-23 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aldosterone / metabolism Blood Pressure / drug effects Captopril / therapeutic use* Child Electrolytes / metabolism Humans Hypertension / drug therapy*, metabolism Kallikreins / urine Middle Aged Proline / analogs & derivatives* Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 147-85-3/Proline; 52-39-1/Aldosterone; 62571-86-2/Captopril; EC 3.4.21.-/Kallikreins; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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