| Long-term effects of calorie restriction on serum sex-hormone concentrations in men. | |
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MedLine Citation:
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PMID: 20096034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calorie restriction (CR) slows aging and consistently reduces circulating sex hormones in laboratory animals. However, nothing is known regarding the long-term effects of CR with adequate nutrition on serum sex-hormone concentration in lean healthy humans. In this study, we measured body composition, and serum total testosterone, total 17-beta-estradiol, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEA-S) concentrations in 24 men (mean age 51.5 +/- 13 years), who had been practicing CR with adequate nutrition for an average of 7.4 +/- 4.5 years, in 24 age- and body fat-matched endurance runners (EX), and 24 age-matched sedentary controls eating Western diets (WD). We found that both the CR and EX volunteers had significantly lower body fat than the WD volunteers (total body fat, 8.7 +/- 4.2%; 10.5 +/- 4.4%; 23.2 +/- 6.1%, respectively; P = 0.0001). Serum total testosterone and the free androgen index were significantly lower, and SHBG was higher in the CR group than in the EX and WD groups (P < or = 0.001). Serum 17beta-estradiol and the estradiol:SHBG ratio were both significantly lower in the CR and EX groups than in the WD group (P < or = 0.005). Serum DHEA-S concentrations were not different between the three groups. These findings demonstrate that, as in long-lived CR rodents, long-term severe CR reduces serum total and free testosterone and increases SHBG concentrations in humans, independently of adiposity. More studies are needed to understand the role of this CR-mediated reduction in sex hormones in modulating the pathogenesis of age-associated chronic diseases such as cancer and the aging process itself. |
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Authors:
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Roberto Cangemi; Alberto J Friedmann; John O Holloszy; Luigi Fontana |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-01-20 |
Journal Detail:
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Title: Aging cell Volume: 9 ISSN: 1474-9726 ISO Abbreviation: Aging Cell Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-06-10 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 101130839 Medline TA: Aging Cell Country: England |
Other Details:
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Languages: eng Pagination: 236-42 Citation Subset: IM |
Affiliation:
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Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Weight Caloric Restriction* Gonadal Steroid Hormones / blood* Humans Male Middle Aged Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR000036-475227/RR/NCRR NIH HHS; P30 DK056341-10/DK/NIDDK NIH HHS; UL1 RR024992/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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