Document Detail

Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women: a randomized controlled trial.
MedLine Citation:
PMID:  7709944     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the long-term effects of calcium supplements or placebo on bone density in healthy women at least 3 years postmenopause. PATIENTS AND METHODS: Eighty-six women from our previously reported 2-year study agreed to continue on their double-blind treatment allocation (1 g elemental calcium or placebo) for a further 2 years, with 78 women (40 on placebo) reaching the 4-year end point. Median (interquartile range) dietary calcium intakes for the whole group were 700 mg (range 540 to 910) per day at baseline, 670 mg (range 480 to 890) per day at 2 years, and 640 mg (range 460 to 880) per day at 4 years. The bone mineral density (BMD) of the total body, lumbar spine, and proximal femur was measured every 6 months by dual-energy, x-ray absorptiometry. RESULTS: There was a sustained reduction in the rate of loss of total body BMD in the calcium group throughout the 4-year study period (P = 0.002), and bone loss was significantly less in the calcium-treated subjects in years 2 through 4 also (difference between groups 0.25% +/- 0.11% per year, P = 0.02). In the lumbar spine, bone loss was reduced in the calcium group in year 1 (P = 0.004), but not subsequently. There was, however, a significant treatment effect at this site over the whole 4-year period (P = 0.03). In the proximal femur, the benefit from calcium treatment also tended to be greater in the first year and was significant over the 4-year study period in the femoral neck (P = 0.03) and the trochanter (P = 0.01). Nine symptomatic fractures occurred in 7 subjects in the placebo group and 2 fractures in 2 subjects receiving calcium (P = 0.037). CONCLUSIONS: Calcium supplementation produces a sustained reduction in the rate of loss of total body BMD in healthy postmenopausal women.
I R Reid; R W Ames; M C Evans; G D Gamble; S J Sharpe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  98     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-08     Completed Date:  1995-05-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-5     Citation Subset:  AIM; IM    
Department of Medicine, University of Auckland, New Zealand.
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MeSH Terms
Absorptiometry, Photon
Bone Density / drug effects*
Calcium / therapeutic use*
Calcium, Dietary / administration & dosage
Double-Blind Method
Fractures, Bone / physiopathology,  prevention & control*
Middle Aged
Osteoporosis, Postmenopausal / physiopathology,  prevention & control*,  radiography
Reg. No./Substance:
0/Calcium, Dietary; 7440-70-2/Calcium
Comment In:
Am J Med. 1995 Apr;98(4):329-30   [PMID:  7709943 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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