Document Detail


Long-term effects of bisoprolol on blood pressure, serum lipids, and HDL-cholesterol in patients with essential hypertension.
MedLine Citation:
PMID:  2439784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the study was to evaluate the effect of continuous therapy with bisoprolol on blood pressure, serum lipids, and HDL-cholesterol over a period of 10 months following an initial 3-month titration and short-term treatment period. The results of the short-term study have been presented in a separate report. Forty-two patients entered into this long-term study, and 41 of them completed the 10-month treatment period. The mean supine blood pressure was 134/85 mm Hg at the end of the short-term study and was maintained at 137/85 mm Hg after 10 months on bisoprolol. At the end of the study, all patients but one had a supine diastolic blood pressure of less than or equal to 90 mm Hg with a dose of 2.5-40 mg bisoprolol. Three of the patients required concomitant use of hydrochlorothiazide to keep this pressure level. A small but statistically significant increase in serum triglycerides was observed from the start of the titration period to the end of the long-term study. Within each study, the changes were not significant. No significant changes were observed for total cholesterol, or for low density lipoprotein (LDL)- or high density lipoprotein (HDL)-cholesterol. The side effects were rare and the usual for beta-blockers.
Authors:
G Frithz; L Weiner
Related Documents :
2369364 - Secular trends in atherosclerosis of coronary arteries and basal cerebral arteries in j...
3944224 - Diuretic-induced laboratory abnormalities that predict ventricular ectopy.
15061604 - Correlation between body mass index and others risk factors for cardiovascular disease ...
7729294 - Visceral adiposity, fasting plasma insulin, and blood pressure in japanese-americans.
2170514 - A functional morphometric study of the cremaster muscle microcirculation in young spont...
2760664 - Blood pressure trends associated with changes in height and weight from early adolescen...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  8 Suppl 11     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1987-08-10     Completed Date:  1987-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S134-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / adverse effects,  therapeutic use*
Adult
Bisoprolol
Blood Pressure / drug effects*
Cholesterol, HDL / blood*
Female
Heart Rate / drug effects
Humans
Hypertension / blood,  drug therapy*,  physiopathology
Lipids / blood*
Male
Middle Aged
Propanolamines / adverse effects,  therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Cholesterol, HDL; 0/Lipids; 0/Propanolamines; 66722-44-9/Bisoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A comparison of the effects of bisoprolol and atenolol on lipoprotein concentrations and blood press...
Next Document:  Clinical evaluation of bisoprolol in patients with hypertension: interim report.