| Long-term effects on bacterial sensitivity patterns of preoperative antibiotic prophylaxis in colorectal surgery. | |
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MedLine Citation:
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PMID: 3673454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since 1973, when doxycycline was introduced as peroperative prophylaxis in elective colorectal surgery at Malmö General Hospital, Sweden, there has been an unchanged and low rate (8-12%) of septic complications in colonic surgery. For treating postoperative infections ampicillin, cefuroxime and piperacillin have been used since 1973, 1980 and 1982 respectively. The sensitivity pattern of E. coli and Klebsiella against these four antibiotics used for prophylaxis and treatment has been followed for the past five years and only minor changes have occurred through the period. However, a lower frequency of antibiotic resistance was recorded for bacteria isolated peroperatively than postoperatively after colorectal surgery or from infection sites from other patients presumably mostly due to selection caused by antibiotics used within the hospital. Due to the good clinical outcome and seemingly lack of development of antibiotic resistance in peroperative isolates, doxycycline still remains a choice for prophylaxis in bowel surgery. |
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Authors:
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M Walder; L Leandoer; A Törnqvist; A Forsgren |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta chirurgica Scandinavica Volume: 153 ISSN: 0001-5482 ISO Abbreviation: Acta Chir Scand Publication Date: 1987 Jul-Aug |
Date Detail:
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Created Date: 1987-11-25 Completed Date: 1987-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7906530 Medline TA: Acta Chir Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 447-52 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, University of Lund, Malmö General Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Ampicillin Resistance Anti-Bacterial Agents / therapeutic use* Cefuroxime / therapeutic use Child Colonic Diseases / surgery* Doxycycline / therapeutic use Female Humans Male Microbial Sensitivity Tests Middle Aged Piperacillin / therapeutic use Premedication* Rectal Diseases / surgery* Surgical Wound Infection / prevention & control* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 55268-75-2/Cefuroxime; 564-25-0/Doxycycline; 61477-96-1/Piperacillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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