Document Detail

Long-term effects of angiotensin II receptor blockade with valsartan on carotid arterial stiffness and hemodynamic alterations in patients with essential hypertension.
MedLine Citation:
PMID:  18633763     Owner:  NLM     Status:  MEDLINE    
Increased arterial stiffness and intima media thickness (IMT) in the common carotid artery (CCA) are related to cardiovascular risk in essential hypertension. Angiotensin II plays an important role in structural and functional changes in the vasculature. In this study, we evaluated the long-term effect of the angiotensin II receptor blocker, valsartan, on IMT, arterial stiffness, and hemodynamics in the CCA in patients with essential hypertension. A prospective 24 month study of treatment with valsartan (80-160 mg/day) was performed in 24 hypertensive patients. An ultrasound of the CCA was carried out to determine IMT, the cross-sectional distensibility coefficient (CSDC), the carotid arterial stiffness index beta, and diastolic flow velocity to systolic flow velocity ratio (Vd/Vs). Treatment with valsartan for 24 months reduced systolic and diastolic blood pressure significantly. Compared to baseline, the decrease in pulse pressure was greater after 24 months treatment than after 12 months treatment. Valsartan did not influence IMT; however, after 24 months, it caused a significant increase in CSDC and a decrease in stiffness index beta compared to baseline. These changes were not observed after 12 months of treatment. In addition, Vd/Vs, a sensitive marker of relative diastolic blood flow, increased after 24 months' treatment with valsartan. These results suggest that long-term treatment with valsartan improves vascular wall function and hemodynamics in patients with essential hypertension.
Takafumi Okura; Sanae Watanabe; Mie Kurata; Mitsuko Koresawa; Jun Irita; Daijiro Enomoto; Masanori Jotoku; Ken-Ichi Miyoshi; Tomikazu Fukuoka; Jitsuo Higaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  30     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-22     Citation Subset:  IM    
Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / pharmacology*,  therapeutic use
Blood Flow Velocity / drug effects
Carotid Artery, Common / drug effects*,  physiopathology,  ultrasonography
Elasticity / drug effects
Hypertension / drug therapy,  physiopathology*,  ultrasonography
Prospective Studies
Tetrazoles / pharmacology*,  therapeutic use
Time Factors
Treatment Outcome
Tunica Media / drug effects,  pathology,  ultrasonography
Valine / analogs & derivatives*,  pharmacology,  therapeutic use
Vascular Resistance / drug effects*
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine

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