Document Detail

Long term effects of amlodipine on organ damage, stroke and life span in stroke prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  8482318     Owner:  NLM     Status:  MEDLINE    
The long term effects of amlodipine, a new long acting Ca2+ channel antagonist on organ damage, stroke and life span, were examined in stroke prone spontaneously hypertensive rats (SHRSPs). Blood pressure of the SHRSPs increased over the first 16 weeks and reached a stable level of about 250 mmHg in controls and about 200 mmHg in the amlodipine treated group. At 15 weeks after starting amlodipine treatment, all control SHRSPs exhibited varying degrees of myocardial fibrosis, proliferative and/or necrotic vasculitis and glomerular lesions, whereas only a few animals in the amlodipine group showed slight lesions. The average life span of animals was estimated to be 43.3 weeks and 71.1 weeks for control and amlodipine groups, respectively, which suggested a 1.6-fold prolongation of their life span by amlodipine treatment. These results indicate that the long term treatment of amlodipine suppresses the incidence of organ damage and stroke in SHRSPs and prolongs their life span.
M Suzuki; K Yamanaka; H Nabata; M Tachibana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  228     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-28     Completed Date:  1993-05-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  IM    
Pharmacology Laboratory, Pfizer Pharmaceuticals Inc., Aichi, Japan.
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MeSH Terms
Amlodipine / therapeutic use*
Cerebrovascular Disorders / etiology,  prevention & control*
Heart / drug effects*
Hypertension / complications,  pathology,  physiopathology*
Kidney / drug effects*,  pathology
Longevity / drug effects
Myocardium / pathology
Rats, Inbred SHR
Survival Rate
Reg. No./Substance:

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