Document Detail


Long-term effectiveness and safety of didanosine combined with lamivudine and efavirenz or nevirapine in antiretroviral-naive patients: a 9-year cohort study in Senegal.
MedLine Citation:
PMID:  21087377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The use of didanosine (ddI) in first-line antiretroviral therapy has been recently promoted for resource-limited settings. We therefore compared the long-term effectiveness and safety of the regimen combining ddI, lamivudine, and efavirenz or nevirapine with that of the WHO-recommended regimen of zidovudine (ZDV), lamivudine, and efavirenz or nevirapine in antiretroviral-naïve patients in Senegal.
METHODS: Observational cohort study of patients enrolled between January 2000 and April 2002 in the Senegalese antiretroviral drug access initiative. Multivariate analyses were performed to compare, between the ddI and ZDV groups, the proportion of patients with a viral load <500 copies/ml during follow-up; the increase in the CD4 cell count; survival; treatment changes and severe adverse events.
RESULTS: Of 151 patients, 71 received the ddI-based treatment and 80 received the ZDV-based treatment. Throughout follow-up, 80-95% of patients had a viral load below 500 copies/ml in both the ddI and ZDV groups (P = 0.5). The CD4 cell count increased after treatment initiation from 176 to 497 cells/mm(3) in the ddI group and from 176 to 567 cells/mm(3) in the ZDV group (P > 0.3). The rate of death tended to be higher in the ddI group (P = 0.06). ddI was less commonly discontinued than ZDV (P = 0.03).
CONCLUSION: The combination of ddI, lamivudine, and efavirenz or nevirapine resulted in sustained viral suppression and immunological recovery.
Authors:
Christian Laurent; Jules Brice Tchatchueng Mbougua; Ndèye Fatou Ngom Guèye; Jean-François Etard; Assane Diouf; Roland Landman; Nicolas Molinari; Pierre-Marie Girard; Papa Salif Sow; Ibra Ndoye; Eric Delaporte;
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-19
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  16     ISSN:  1365-3156     ISO Abbreviation:  Trop. Med. Int. Health     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-04-25     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / adverse effects,  therapeutic use*
Antiretroviral Therapy, Highly Active / adverse effects,  methods
Benzoxazines / adverse effects,  therapeutic use
CD4 Lymphocyte Count
Didanosine / adverse effects,  therapeutic use
Drug Therapy, Combination / adverse effects,  methods
Female
HIV Infections / drug therapy*,  immunology,  virology
HIV-1*
Humans
Lamivudine / adverse effects,  therapeutic use
Male
Middle Aged
Nevirapine / adverse effects,  therapeutic use
Treatment Outcome
Viral Load
Zidovudine / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Benzoxazines; 2T8Q726O95/Lamivudine; 4B9XT59T7S/Zidovudine; 99DK7FVK1H/Nevirapine; JE6H2O27P8/efavirenz; K3GDH6OH08/Didanosine
Investigator
Investigator/Affiliation:
I Ndoye / ; P de Beaudrap / ; E Delaporte / ; J F Etard / ; C Laurent / ; B Taverne / ; M M Bitèye / ; A B Dieng / ; A Diouf / ; A Sarr / ; L Zié / ; V Cilote / ; I Lanièce / ; I Ndiaye / ; A Ndir / ; C T Ndour / ; C S Senghor / ; P S Sow / ; M Basty Fall / ; N M Dia Badiane / ; N Diakhaté / ; M Diallo / ; L M Diouf / ; N F Ngom Guèye / ; K Ba Fall / ; P M Guèye / ; C Périno / ; P A Diaw / ; H Diop Ndiaye / ; S Mboup / ; N C Touré Kane / ; K Sow / ; K Diop / ; B Ndiaye / ; M Ciss / ; A Desclaux /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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