Document Detail

Long-term effect of xylitol gum use on mutans streptococci in adults.
MedLine Citation:
PMID:  17426399     Owner:  NLM     Status:  MEDLINE    
Many studies have shown the effects of chewing xylitol gum on mutans streptococci (MS) over short- and long-term periods in children; however, few studies have addressed long-term periods in adults. The objective of this investigation was to examine for 6 months the effects of chewing xylitol gum on MS in saliva and plaque in 127 adults (mean age 28.0 years). The participants were assigned to three groups according to gum type, in part taking preference for flavor into account and in part at random: xylitol (XYL), maltitol (MAL) and control (CR); 33, 34 and 27 subjects in each group, respectively, completed the trial. Daily gum use of the XYL and MAL groups was 7.9 and 7.1 g, respectively. MS levels, which declined significantly in saliva (p < 0.05) and plaque (p < 0.001) in the XYL group after 6 months, exhibited a significant increase in plaque in the MAL group (p < 0.001). Differences in relative changes of MS levels in plaque during the experimental period were significant between the XYL group and the CR (p < 0.05) and MAL groups (p < 0.001). Differences in relative change of amount of plaque during the experimental period were not statistically significant between the groups. The present study demonstrated that chewing xylitol gum for 6 months continued to inhibit the growth of mutans streptococci in adults.
S Haresaku; T Hanioka; A Tsutsui; M Yamamoto; T Chou; Y Gunjishima
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Caries research     Volume:  41     ISSN:  1421-976X     ISO Abbreviation:  Caries Res.     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-04-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  D; IM    
Copyright Information:
Copyright 2007 S. Karger AG, Basel.
Department of Preventive and Public Health Dentistry, Oral Public Health, Fukuoka Dental College, Fukuoka, Japan.
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MeSH Terms
Chewing Gum*
Colony Count, Microbial
DMF Index
Dental Plaque / microbiology
Longitudinal Studies
Maltose / analogs & derivatives,  pharmacology
Middle Aged
Saliva / microbiology
Statistics, Nonparametric
Streptococcus mutans / drug effects*
Sugar Alcohols / pharmacology
Sweetening Agents / pharmacology*
Xylitol / pharmacology*
Reg. No./Substance:
0/Chewing Gum; 0/Sugar Alcohols; 0/Sweetening Agents; 585-88-6/maltitol; 69-79-4/Maltose; 87-99-0/Xylitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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