| Long-term effect of somatostatin 14 on mouse stomach, antrum, intestine and exocrine pancreas. | |
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MedLine Citation:
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PMID: 2858147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice were injected 3 times a day for 12 days with 8 micrograms/kg of somatostatin 14 which caused a hypoplasia of parietal and goblet cells, a hypotrophy and hypofunctionality of pancreatic acinar cells with a decrease in lipase and chymotrypsin activities, a decrease in the secretory fuction of the Brunner gland and in the number of dark granules of G cells. Neither villous and microvillous areas nor brush border hydrolase activities were affected. The number of peptic cells and Paneth cells increase as the level of pepsin and lysozyme. Mice were injected 4 times per hour with 2 micrograms/kg of somatostatin. 2 h after the first injection of somatostatin and 90 min after a single injection of tritiated thymidine, fundic, antral, jejunal and ileal labelling indexes strongly decrease (maximal effect in ileum). The inhibitory effect of somatostatin on the digestive epithelial cell proliferation compared to its long-term action only directed on specific cell types evokes probable compensatory mechanisms induced to maintain the equilibrium of the digestive epithelia. |
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Authors:
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F Senegas-Balas; D Balas; L Pradayrol; J Laval; C Bertrand; A Ribet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta anatomica Volume: 121 ISSN: 0001-5180 ISO Abbreviation: Acta Anat (Basel) Publication Date: 1985 |
Date Detail:
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Created Date: 1985-03-29 Completed Date: 1985-03-29 Revised Date: 2007-07-02 |
Medline Journal Info:
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Nlm Unique ID: 0370272 Medline TA: Acta Anat (Basel) Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 124-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Cell Count Gastric Mucosa / drug effects Intestinal Mucosa / drug effects Intestine, Small / cytology, drug effects* Kinetics Male Mice Pancreas / drug effects* Parietal Cells, Gastric / drug effects, ultrastructure Pyloric Antrum / cytology, drug effects* Somatostatin / pharmacology* Stomach / cytology, drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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51110-01-1/Somatostatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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