Document Detail

Long-term effect of rehabilitation in coronary artery disease patients: randomized clinical trial of the impact of exercise volume.
MedLine Citation:
PMID:  20176771     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether exercise volume during phase II rehabilitation affects long-term clinical benefits in patients with coronary artery disease. DESIGN: Prospective randomized clinical trial with long-term follow-up. SETTING: Hospital outpatient clinic. SUBJECTS: Coronary artery disease patients (age 65 +/- 9 years, 82% males) attending a phase II rehabilitation programme were randomized into two groups of exercise volumes: 40- versus 60-minute training sessions. Patients exercised for three days per week for seven weeks, at 65% of baseline oxygen uptake capacity. Next, they were followed up for 18 months. Out of 165 patients with coronary artery disease who completed the exercise intervention, 119 attended the 18-month follow-up assessment. MAIN MEASUREMENTS: Body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, smoking behaviour, habitual physical activity, cardiovascular disease incidence and mortality. RESULTS: In total population, a significant worsening of various cardiovascular disease risk factors was found at 18 months follow-up (P<0.05), and few patients (27% of total group) adhered to the recommended minimal physical activity level. No difference in change of body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, and smoking behaviour was seen between different exercise volumes (P>0.05). In addition, total cardiovascular disease incidence (13% versus 22% in 40- versus 60-minute group, respectively) and habitual physical activity were not different between groups (P>0.05). CONCLUSION: In patients with coronary artery disease following cardiac rehabilitation, the cardiovascular disease risk profile worsened significantly during long-term follow-up. A smaller exercise volume during phase II rehabilitation generated equal long-term clinical benefits compared to a greater exercise volume.
Dominique Hansen; Paul Dendale; Anita Raskin; Annick Schoonis; Jan Berger; Irmien Vlassak; Romain Meeusen
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-02-22
Journal Detail:
Title:  Clinical rehabilitation     Volume:  24     ISSN:  1477-0873     ISO Abbreviation:  Clin Rehabil     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802181     Medline TA:  Clin Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
Jessa Hospital, Rehabilitation and Health Centre, Heart Centre Hasselt, Hasselt and Vrije Universiteit Brussel, Department of Human Physiology and Sportsmedicine, Brussels, Belgium.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Blood Glucose / analysis
Blood Pressure
C-Reactive Protein / analysis
Coronary Artery Disease / rehabilitation*
Coronary Restenosis / epidemiology
Lipids / blood
Middle Aged
Myocardial Infarction / epidemiology
Patient Compliance
Platelet Aggregation Inhibitors / therapeutic use
Prospective Studies
Risk Factors
Smoking / epidemiology
Time Factors
Waist Circumference
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Lipids; 0/Platelet Aggregation Inhibitors; 9007-41-4/C-Reactive Protein

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