| Long-term effect of rehabilitation in coronary artery disease patients: randomized clinical trial of the impact of exercise volume. | |
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MedLine Citation:
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PMID: 20176771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether exercise volume during phase II rehabilitation affects long-term clinical benefits in patients with coronary artery disease. DESIGN: Prospective randomized clinical trial with long-term follow-up. SETTING: Hospital outpatient clinic. SUBJECTS: Coronary artery disease patients (age 65 +/- 9 years, 82% males) attending a phase II rehabilitation programme were randomized into two groups of exercise volumes: 40- versus 60-minute training sessions. Patients exercised for three days per week for seven weeks, at 65% of baseline oxygen uptake capacity. Next, they were followed up for 18 months. Out of 165 patients with coronary artery disease who completed the exercise intervention, 119 attended the 18-month follow-up assessment. MAIN MEASUREMENTS: Body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, smoking behaviour, habitual physical activity, cardiovascular disease incidence and mortality. RESULTS: In total population, a significant worsening of various cardiovascular disease risk factors was found at 18 months follow-up (P<0.05), and few patients (27% of total group) adhered to the recommended minimal physical activity level. No difference in change of body anthropometrics, resting haemodynamics, blood lipid profile, glycaemia, and C-reactive protein level, and smoking behaviour was seen between different exercise volumes (P>0.05). In addition, total cardiovascular disease incidence (13% versus 22% in 40- versus 60-minute group, respectively) and habitual physical activity were not different between groups (P>0.05). CONCLUSION: In patients with coronary artery disease following cardiac rehabilitation, the cardiovascular disease risk profile worsened significantly during long-term follow-up. A smaller exercise volume during phase II rehabilitation generated equal long-term clinical benefits compared to a greater exercise volume. |
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Authors:
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Dominique Hansen; Paul Dendale; Anita Raskin; Annick Schoonis; Jan Berger; Irmien Vlassak; Romain Meeusen |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-02-22 |
Journal Detail:
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Title: Clinical rehabilitation Volume: 24 ISSN: 1477-0873 ISO Abbreviation: Clin Rehabil Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802181 Medline TA: Clin Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 319-27 Citation Subset: IM |
Affiliation:
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Jessa Hospital, Rehabilitation and Health Centre, Heart Centre Hasselt, Hasselt and Vrije Universiteit Brussel, Department of Human Physiology and Sportsmedicine, Brussels, Belgium. rmeeusen@vub.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use Aged Blood Glucose / analysis Blood Pressure C-Reactive Protein / analysis Coronary Artery Disease / rehabilitation* Coronary Restenosis / epidemiology Exercise* Female Humans Incidence Lipids / blood Male Middle Aged Myocardial Infarction / epidemiology Patient Compliance Platelet Aggregation Inhibitors / therapeutic use Prospective Studies Retreatment Risk Factors Smoking / epidemiology Time Factors Waist Circumference |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Blood Glucose; 0/Lipids; 0/Platelet Aggregation Inhibitors; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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