| Long-term effect of continuous positive airway pressure on BP in patients with hypertension and sleep apnea. | |
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MedLine Citation:
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PMID: 17925415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To analyze the long-term effect of continuous positive airway pressure (CPAP) on ambulatory BP in patients with obstructive sleep apnea (OSA) and hypertension, and to identify subgroups of patients for whom CPAP could be more effective. METHODS: We conducted a prospective, long-term follow-up trial (24 months) in 55 patients with OSA and hypertension (mean CPAP use, 5.3 +/- 1.9 h/d [+/- SD]). Twenty-four-hour ambulatory BP monitoring (ABPM) was measured at baseline and after intervention with CPAP on an intention-to-treat basis. In addition, the correlation between the changes in 24-h mean arterial pressure (24hMAP) and CPAP compliance, OSA severity, and baseline ABPM was assessed. RESULTS: At the end of follow-up, a significant decrease was shown only in diastolic BP (- 2.2 mm Hg; 95% confidence interval [CI], - 4.2 to - 0.1; p = 0.03) but not in 24hMAP or other ABPM parameters. However, a correlation between changes in 24hMAP and baseline systolic BP (r = - 0.43, p = 0.001), diastolic BP (r = - 0.38, p = 0.004), and hours of use of CPAP (r = - 0.30, p = 0.02) was observed. A significant decrease in the 24hMAP was achieved in a subgroup of patients with incompletely controlled hypertension at entry (- 4.4 mm Hg; 95% CI, - 7.9 to - 0.9 mm Hg; p = 0.01), as well as in those with CPAP compliance > 5.3 h/d (- 5.3 mm Hg; 95% CI, - 9.5 to - 1.2 mm Hg; p = 0.01). Linear regression analysis showed that baseline systolic BP and hours of CPAP were independent predictors of reductions in BP with CPAP. CONCLUSION: Long-term CPAP reduced BP modestly in the whole sample. However, patients with higher BP at entry and good CPAP compliance achieved significant reductions in BP. |
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Authors:
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Francisco Campos-Rodriguez; Jose Perez-Ronchel; Antonio Grilo-Reina; Jorge Lima-Alvarez; Maria A Benitez; Carmen Almeida-Gonzalez |
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Publication Detail:
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Type: Journal Article Date: 2007-10-09 |
Journal Detail:
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Title: Chest Volume: 132 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-14 Completed Date: 2008-02-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1847-52 Citation Subset: AIM; IM |
Affiliation:
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Departments of Respiratory Medicine, Valme University Hospital 41020 Sevilla, Spain. fcamposr@telefonica.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Monitoring, Ambulatory Continuous Positive Airway Pressure* Female Follow-Up Studies Humans Hypertension / etiology*, physiopathology, therapy* Longitudinal Studies Male Middle Aged Prospective Studies Risk Factors Sleep Apnea Syndromes / complications*, physiopathology, therapy* Statistics, Nonparametric Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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