Document Detail


Long-term effect of Bifidobacteria and Neosugar on precursor lesions of colonic cancer in CF1 mice.
MedLine Citation:
PMID:  1775387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This investigation was undertaken to study the role of Bifidobacteria and bifidogenic factor Neosugar in the process of 1,2-dimethylhydrazine-induced colonic carcinogenesis in CF1 mice. Intestinal colonization and selective proliferation of Bifidobacteria were achieved by oral administration of indigenous Bifidobacteria and the incorporation of 5% Neosugar in the diet of animals. The Bifidobacteria were isolated from the feces of CF1 mice and were identified to be Bifidobacterium pseudolongum biovar b. This incidence of aberrant crypts and foci were significantly lower 38 weeks after the last injection of the carcinogen in animals fed Bifidobacteria than in animals treated with the carcinogen alone. The aberrance also appeared to be confined to the more distal end of the colon in animals fed bifidogenic diet. Such changes in the precursor lesions of colonic carcinogenesis are presumably due to the increase in the number of Bifidobacteria and their acidifying action in the lower intestinal tract of the animals.
Authors:
M Koo; A V Rao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  16     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bifidobacterium / physiology*
Colonic Neoplasms / pathology,  prevention & control*
Female
Hydrogen-Ion Concentration
Mice
Oligosaccharides / pharmacology*
Precancerous Conditions / pathology,  prevention & control*
Sweetening Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Oligosaccharides; 0/Sweetening Agents; 88385-81-3/neosugar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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