Document Detail

Long-term effect of Bifidobacteria and Neosugar on precursor lesions of colonic cancer in CF1 mice.
MedLine Citation:
PMID:  1775387     Owner:  NLM     Status:  MEDLINE    
This investigation was undertaken to study the role of Bifidobacteria and bifidogenic factor Neosugar in the process of 1,2-dimethylhydrazine-induced colonic carcinogenesis in CF1 mice. Intestinal colonization and selective proliferation of Bifidobacteria were achieved by oral administration of indigenous Bifidobacteria and the incorporation of 5% Neosugar in the diet of animals. The Bifidobacteria were isolated from the feces of CF1 mice and were identified to be Bifidobacterium pseudolongum biovar b. This incidence of aberrant crypts and foci were significantly lower 38 weeks after the last injection of the carcinogen in animals fed Bifidobacteria than in animals treated with the carcinogen alone. The aberrance also appeared to be confined to the more distal end of the colon in animals fed bifidogenic diet. Such changes in the precursor lesions of colonic carcinogenesis are presumably due to the increase in the number of Bifidobacteria and their acidifying action in the lower intestinal tract of the animals.
M Koo; A V Rao
Related Documents :
4041127 - Influence of dietary cis- and trans-fat on 1,2-dimethylhydrazine-induced colon tumors a...
24640797 - Importance of measuring non-hdl cholesterol in type 2 diabetes patients.
23757287 - Facelift- and circum-occipital incision placement for fat extirpation of the neck in ma...
12065087 - A bitter diterpenoid furanolactone columbin from calumbae radix inhibits azoxymethane-i...
10050267 - Effect of meat (beef, chicken, and bacon) on rat colon carcinogenesis.
7300117 - Nitrogen and urea metabolism during continuous ambulatory peritoneal dialysis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  16     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  249-57     Citation Subset:  IM    
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bifidobacterium / physiology*
Colonic Neoplasms / pathology,  prevention & control*
Hydrogen-Ion Concentration
Oligosaccharides / pharmacology*
Precancerous Conditions / pathology,  prevention & control*
Sweetening Agents / pharmacology*
Reg. No./Substance:
0/Oligosaccharides; 0/Sweetening Agents; 88385-81-3/neosugar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of dietary selenium and magnesium on human mammary tumor growth in athymic nude mice.
Next Document:  Dietary cholesterol, fatty acids, and the risk of lung cancer among men.