Document Detail

Long-term durability of a st. Jude medical x-cell bioprosthesis.
MedLine Citation:
PMID:  22364988     Owner:  NLM     Status:  In-Data-Review    
An 82-year-old female had undergone aortic valve replacement with a 23-mm St. Jude Medical X-Cell porcine bioprosthesis (XCB), a glutaraldehyde-fixed valve subjected to a decellularization process. More than 13 years later, she required a repeated operation because of XCB structural failure. Pathologic examination of an unused XCB as control showed that many interstitial cells were still present in the porcine cusps. The XCB explant exhibited gross mineralization on radiograph, fairly well-preserved fibrosa, lack of interstitial and endothelial cells, scattered empty spaces with plasma insudation, and calcific deposits. Ultrastructural examination revealed calcium deposition on collagen fibers and cell debris. Partial cusp decellularization observed in an XCB was not effective in preventing mineralization and most likely should be associated with other antimineralization treatments as well as methods favoring cell repopulation in vitro or in vivo.
Uberto Bortolotti; Michele Celiento; Mila Della Barbera; Stefano Pratali; Gaetano Thiene; Marialuisa Valente
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  93     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  972-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.
Cardiac Thoracic and Vascular Department, University of Pisa Medical School, Pisa, Italy.
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