Document Detail

Long-term disease stabilization in a patient with castration-resistant metastatic prostate cancer by the addition of lenalidomide to low-dose dexamethasone and celecoxib.
MedLine Citation:
PMID:  22868509     Owner:  NLM     Status:  In-Data-Review    
Background: Treatment of castrationresistant prostate cancer (CRPC) remains a challenge considering that most patients are elderly men with significant comorbidities. Alternative treatment strategies to cytotoxic therapy should be explored. There is evidence that the continuous administration of cyclooxygenase 2 (COX2) inhibitors and the immunomodulatory agents thalidomide or lenalidomide can result in longterm disease stabilization. Case Report: A 70-year-old patient with castrationresistant metastatic prostate cancer was treated with a combination of lowdose dexamethasone, celecoxib and subsequently lenalidomide. The patient had longterm disease stabilization for 33 months and a very good performance status despite moderate side effects, i.e. moderate Cushing's syndrome and mild laboratory hematologic toxicity. Conclusion: The addition of lenalidomide to low-dose dexamethasone and celecoxib resulted in an impressive longterm disease stabilization of CRPC in this patient, allowing him to lead an active life with a good quality of life.
Norbert Marschner; Matthias Zaiss
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Publication Detail:
Type:  Journal Article     Date:  2012-04-24
Journal Detail:
Title:  Onkologie     Volume:  35     ISSN:  1423-0240     ISO Abbreviation:  Onkologie     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  279-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Praxis für Interdisziplinäre Onkologie und Hämatologie, Freiburg i.Br., Germany.
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