Document Detail


Long-term disability from acute childhood Japanese encephalitis in Shanghai, China.
MedLine Citation:
PMID:  17827373     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We traced 85 Japanese encephalitis (JE) patients, 6-27 years after hospitalizations. The first control group was made up of 73 non-JE encephalitis patients 6-27 years previously, whereas the second control group was made up 78 neighborhood residents, matched to the 78 surviving JE cases by age, sex, and residence. All subjects were examined with neurologic examinations, intelligence quotient (IQ) measurement, Mini-Mental State Examinations (MMSE), and activities of daily living (ADL) assessments. At follow-up, 22% of JE patients had objective neurologic deficits compared with 3% of non-JE encephalitis patients. Moreover, 28% of JE patients had subnormal IQs, as opposed to 2% non-JE encephalitis patients. Abnormal ADL scores were only noted in 15% JE patients. All neighborhood controls had normal examination results, and one non-JE encephalitis case showed mildly reduced IQ. The study showed that significant neurologic and overall functional disability were evident in a high proportion of JE survivors many years after their index hospitalizations.
Authors:
Ding Ding; Zhen Hong; Shou-Jun Zhao; John D Clemens; Bin Zhou; Bei Wang; Mao-Sheng Huang; Jun Zeng; Qi-Hao Guo; Wei Liu; Fang-Biao Tao; Zhi-Yi Xu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  77     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  528-33     Citation Subset:  AIM; IM    
Affiliation:
Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Case-Control Studies
Child
Child, Preschool
China
Encephalitis, Japanese / complications*
Female
Follow-Up Studies
Humans
Male
Mental Retardation / complications*

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