Document Detail


Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial.
MedLine Citation:
PMID:  18973896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate long-term cyclic and continuous administration of oral contraceptive pills (OCP) in preventing ovarian endometrioma recurrence after laparoscopic cystectomy. DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary care University Hospital. PATIENT(S): Two hundred thirty-nine women who underwent laparoscopic excision of ovarian endometriomas. INTERVENTION(S): Patients were divided randomly into three groups: nonusers receiving no therapy and cyclic and continuous users receiving low-dose, monophasic OCP for 24 months in cyclic or continuous administration, respectively. MAIN OUTCOME MEASURE(S): Endometrioma recurrence, size of recurrent endometrioma, and growth rate during at least 2 years follow-up evaluated by transvaginal ultrasonography. RESULT(S): The crude recurrence rate within 24 months was significantly lower in cyclic (14.7%) and continuous users (8.2%) compared with nonusers (29%). The recurrence-free survival was significantly lower in nonusers compared with cyclic and continuous users. The mean recurrent endometrioma diameter at first observation was significantly lower in cyclic (2.17 +/- 0.45 cm) and continuous users (1.71 +/- 0.19 cm) compared with nonusers (2.73 +/- 0.56 cm). The mean diameter increase every 6 months of follow-up was significantly reduced in cyclic users (0.31 +/- 0.18 cm) and continuous users (0.25 +/- 0.09 cm) versus nonusers (0.48 +/- 0.3 cm). No significant differences between cyclic users and continuous users in terms of endometrioma recurrence were demonstrated. CONCLUSION(S): Long-term cyclic and continuous postoperative use of OCP can effectively reduce and delay endometrioma recurrence.
Authors:
Renato Seracchioli; Mohamed Mabrouk; Clarissa Frasc?; Linda Manuzzi; Giulia Montanari; Arianna Keramyda; Stefano Venturoli
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2008-10-29
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Minimally Invasive Gynaecological Surgery Unit, Reproductive Medicine Unit, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. seracchioli@aosp.bo.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Combined Modality Therapy
Contraceptives, Oral, Combined / administration & dosage*
Contraceptives, Oral, Hormonal / administration & dosage*
Contraceptives, Oral, Sequential / administration & dosage*
Disease-Free Survival
Drug Administration Schedule
Endometriosis / drug therapy*,  surgery,  ultrasonography
Ethinyl Estradiol / administration & dosage*
Female
Humans
Kaplan-Meiers Estimate
Laparoscopy*
Norpregnenes / administration & dosage*
Ovarian Diseases / drug therapy*,  surgery,  ultrasonography
Prospective Studies
Recurrence / prevention & control
Severity of Illness Index
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 0/Contraceptives, Oral, Hormonal; 0/Contraceptives, Oral, Sequential; 0/Norpregnenes; 57-63-6/Ethinyl Estradiol; 60282-87-3/Gestodene
Comments/Corrections
Comment In:
Fertil Steril. 2009 May;91(5):e40; author reply e41   [PMID:  19328475 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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