| Long-term cyclic and continuous oral contraceptive therapy and endometrioma recurrence: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 18973896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate long-term cyclic and continuous administration of oral contraceptive pills (OCP) in preventing ovarian endometrioma recurrence after laparoscopic cystectomy. DESIGN: Prospective, randomized, controlled trial. SETTING: Tertiary care University Hospital. PATIENT(S): Two hundred thirty-nine women who underwent laparoscopic excision of ovarian endometriomas. INTERVENTION(S): Patients were divided randomly into three groups: nonusers receiving no therapy and cyclic and continuous users receiving low-dose, monophasic OCP for 24 months in cyclic or continuous administration, respectively. MAIN OUTCOME MEASURE(S): Endometrioma recurrence, size of recurrent endometrioma, and growth rate during at least 2 years follow-up evaluated by transvaginal ultrasonography. RESULT(S): The crude recurrence rate within 24 months was significantly lower in cyclic (14.7%) and continuous users (8.2%) compared with nonusers (29%). The recurrence-free survival was significantly lower in nonusers compared with cyclic and continuous users. The mean recurrent endometrioma diameter at first observation was significantly lower in cyclic (2.17 +/- 0.45 cm) and continuous users (1.71 +/- 0.19 cm) compared with nonusers (2.73 +/- 0.56 cm). The mean diameter increase every 6 months of follow-up was significantly reduced in cyclic users (0.31 +/- 0.18 cm) and continuous users (0.25 +/- 0.09 cm) versus nonusers (0.48 +/- 0.3 cm). No significant differences between cyclic users and continuous users in terms of endometrioma recurrence were demonstrated. CONCLUSION(S): Long-term cyclic and continuous postoperative use of OCP can effectively reduce and delay endometrioma recurrence. |
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Authors:
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Renato Seracchioli; Mohamed Mabrouk; Clarissa Frasc?; Linda Manuzzi; Giulia Montanari; Arianna Keramyda; Stefano Venturoli |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-10-29 |
Journal Detail:
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Title: Fertility and sterility Volume: 93 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 52-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Minimally Invasive Gynaecological Surgery Unit, Reproductive Medicine Unit, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. seracchioli@aosp.bo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Combined Modality Therapy Contraceptives, Oral, Combined / administration & dosage* Contraceptives, Oral, Hormonal / administration & dosage* Contraceptives, Oral, Sequential / administration & dosage* Disease-Free Survival Drug Administration Schedule Endometriosis / drug therapy*, surgery, ultrasonography Ethinyl Estradiol / administration & dosage* Female Humans Kaplan-Meiers Estimate Laparoscopy* Norpregnenes / administration & dosage* Ovarian Diseases / drug therapy*, surgery, ultrasonography Prospective Studies Recurrence / prevention & control Severity of Illness Index Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Combined; 0/Contraceptives, Oral, Hormonal; 0/Contraceptives, Oral, Sequential; 0/Norpregnenes; 57-63-6/Ethinyl Estradiol; 60282-87-3/Gestodene |
| Comments/Corrections | |
Comment In:
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Fertil Steril. 2009 May;91(5):e40; author reply e41
[PMID:
19328475
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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