Document Detail

Long-term control of hypertension in dialysis patients by low dose atenolol.
MedLine Citation:
PMID:  12027136     Owner:  NLM     Status:  MEDLINE    
Hypertension in dialysis patients is considered a major factor in cardiovascular mortality. We investigated long-term efficacy of intermittent atenolol (AT) administration in 10 (7M/3F) hypertensive dialysis patients, age 60.5 (38-72), on dialysis for 56.5 months (8-156) thrice per week (10.5-13.5 h/w) (A). A similar group of 11 normotensive patients served as controls (B). Hypertension was defined as BP> 140/90 (day) and >120/80 mmHg (night) by a 44-h ambulatory BP monitoring (ABPM) after the mid-week session. Dialysis ultrafiltration, hematology, biochemistry were similar in A and B. Atenolol was started on an alternate day, 37.5 mg/w and increased as needed. After 34 days (6-80) and a dose of 68.75 (37.5-450) mg/w, BP dropped (ABPM: MAP 104+/-11.5 to 95.6+/-10.4 mmHg, P=0.0025) similar to controls and daytime HR dropped: 84.6+/-9.2 to 69.3+/-8.2, P=0.0008 and at night: 79.5+/-7.6 to 68.6+/-8.6 b/1' becoming lower than in B: 83+/-10.8/69.3+/-8.2, P=0.009 and 80.5+/-11.7/68.6+/-8.6 b/1' (P=0. 02). Six months later ABPM in A as well as echocardiography in A and B remained unchanged. Moderate, volume independent hypertension in stable dialysis patients is easily controlled during the interdialytic period by small intermittent atenolol doses.
D A Vlassopoulos; D G Mentzikof; D K Hadjiyannakos; C V Noussias; S M Karras; V E Hadjiconstantinou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  25     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-24     Completed Date:  2002-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  269-75     Citation Subset:  IM    
Nephrology Department, A. Fleming Hospital, Athens, Greece.
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MeSH Terms
Adrenergic beta-Antagonists / administration & dosage*
Antihypertensive Agents / administration & dosage*
Atenolol / administration & dosage*
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Heart Rate
Hypertension / diagnosis,  drug therapy*
Kidney Failure, Chronic / metabolism,  physiopathology,  therapy
Middle Aged
Renal Dialysis*
Weight Gain
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 29122-68-7/Atenolol

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