| Long-term control of hypertension in dialysis patients by low dose atenolol. | |
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MedLine Citation:
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PMID: 12027136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension in dialysis patients is considered a major factor in cardiovascular mortality. We investigated long-term efficacy of intermittent atenolol (AT) administration in 10 (7M/3F) hypertensive dialysis patients, age 60.5 (38-72), on dialysis for 56.5 months (8-156) thrice per week (10.5-13.5 h/w) (A). A similar group of 11 normotensive patients served as controls (B). Hypertension was defined as BP> 140/90 (day) and >120/80 mmHg (night) by a 44-h ambulatory BP monitoring (ABPM) after the mid-week session. Dialysis ultrafiltration, hematology, biochemistry were similar in A and B. Atenolol was started on an alternate day, 37.5 mg/w and increased as needed. After 34 days (6-80) and a dose of 68.75 (37.5-450) mg/w, BP dropped (ABPM: MAP 104+/-11.5 to 95.6+/-10.4 mmHg, P=0.0025) similar to controls and daytime HR dropped: 84.6+/-9.2 to 69.3+/-8.2, P=0.0008 and at night: 79.5+/-7.6 to 68.6+/-8.6 b/1' becoming lower than in B: 83+/-10.8/69.3+/-8.2, P=0.009 and 80.5+/-11.7/68.6+/-8.6 b/1' (P=0. 02). Six months later ABPM in A as well as echocardiography in A and B remained unchanged. Moderate, volume independent hypertension in stable dialysis patients is easily controlled during the interdialytic period by small intermittent atenolol doses. |
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Authors:
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D A Vlassopoulos; D G Mentzikof; D K Hadjiyannakos; C V Noussias; S M Karras; V E Hadjiconstantinou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of artificial organs Volume: 25 ISSN: 0391-3988 ISO Abbreviation: Int J Artif Organs Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-05-24 Completed Date: 2002-11-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802649 Medline TA: Int J Artif Organs Country: Italy |
Other Details:
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Languages: eng Pagination: 269-75 Citation Subset: IM |
Affiliation:
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Nephrology Department, A. Fleming Hospital, Athens, Greece. renquest@internet.gr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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administration & dosage* Adult Aged Antihypertensive Agents / administration & dosage* Atenolol / administration & dosage* Blood Pressure / drug effects Blood Pressure Monitoring, Ambulatory Echocardiography Female Heart Rate Humans Hypertension / diagnosis, drug therapy* Kidney Failure, Chronic / metabolism, physiopathology, therapy Male Middle Aged Renal Dialysis* Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 29122-68-7/Atenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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