| Long-term, continuous treatment with both oral and transdermal nitrates increases cardiac events in healed myocardial infarction patients. | |
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MedLine Citation:
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PMID: 12143944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was performed to investigate the effects of continuous dosing of oral, transdermal (patch), and a combination of the two with nitrate treatments on cardiac events in patients with healed myocardial infarction. In total, 1,291 patients with healed myocardial infarction were assigned 2 groups: treatment with nitrates (n=713) or nontreatment (n=578). Nitrate treatment was subdivided into 3 groups: patch group (n=149), oral group (n=504), and combination group (n=60). The mean observation period was 17.4 +/- 21.1 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics were also compared among the 4 groups to determine any effects on outcome. Among the patients with patch, oral, and combination groups, cardiac events occurred 3.4%, 6.7%, 10.0%, respectively, whereas only 2.9% of the patients treated without nitrates had cardiac events. The incidence of cardiac events was significantly greater in patients with oral nitrates and combination groups compared to patients without nitrates (p<0.01, respectively). Continuous dosing of long-term treatment with both oral and transdermal nitrates increased cardiac events in healed myocardial infarction patients. |
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Authors:
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Ken Kanamasa; Takahiro Hayashi; Akio Kimura; Akiko Ikeda; Kinji Ishikawa |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Angiology Volume: 53 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-07-29 Completed Date: 2002-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 399-408 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan. kanamasa@med.kindai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Administration, Oral Female Follow-Up Studies Heart Diseases / chemically induced* Humans Male Middle Aged Myocardial Infarction / drug therapy*, mortality Nitrates / administration & dosage*, adverse effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Nitrates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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