Document Detail

Long-term, continuous treatment with both oral and transdermal nitrates increases cardiac events in healed myocardial infarction patients.
MedLine Citation:
PMID:  12143944     Owner:  NLM     Status:  MEDLINE    
This study was performed to investigate the effects of continuous dosing of oral, transdermal (patch), and a combination of the two with nitrate treatments on cardiac events in patients with healed myocardial infarction. In total, 1,291 patients with healed myocardial infarction were assigned 2 groups: treatment with nitrates (n=713) or nontreatment (n=578). Nitrate treatment was subdivided into 3 groups: patch group (n=149), oral group (n=504), and combination group (n=60). The mean observation period was 17.4 +/- 21.1 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics were also compared among the 4 groups to determine any effects on outcome. Among the patients with patch, oral, and combination groups, cardiac events occurred 3.4%, 6.7%, 10.0%, respectively, whereas only 2.9% of the patients treated without nitrates had cardiac events. The incidence of cardiac events was significantly greater in patients with oral nitrates and combination groups compared to patients without nitrates (p<0.01, respectively). Continuous dosing of long-term treatment with both oral and transdermal nitrates increased cardiac events in healed myocardial infarction patients.
Ken Kanamasa; Takahiro Hayashi; Akio Kimura; Akiko Ikeda; Kinji Ishikawa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Angiology     Volume:  53     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-07-29     Completed Date:  2002-09-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-408     Citation Subset:  IM    
First Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Follow-Up Studies
Heart Diseases / chemically induced*
Middle Aged
Myocardial Infarction / drug therapy*,  mortality
Nitrates / administration & dosage*,  adverse effects*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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