Document Detail

Long term consequences of oxygen therapy in the neonatal period.
MedLine Citation:
PMID:  20452844     Owner:  NLM     Status:  MEDLINE    
Preterm and term infants are frequently exposed to high concentrations of oxygen for prolonged periods. In experimental models, high and prolonged oxygen exposures cause delayed alveolar septation and a bronchopulmonary dysplasia phenotype. Often, however, the oxygen exposure is tolerated in that the infants recover without severe lung or systemic injury. Multiple exposures change oxygen sensitivity in adult and newborn animals. Examples are antenatal corticosteroids, inflammatory mediators or preconditioning with oxygen, which will increase tolerance to oxygen injury. Intrauterine growth restriction or postnatal nutritional deficits will increase oxygen injury. Different infants probably have quite variable sensitivities to oxygen injury, but there are no biomarkers available to predict the risk of oxygen injury.
Alan H Jobe; Suhas G Kallapur
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-05-10
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  15     ISSN:  1878-0946     ISO Abbreviation:  Semin Fetal Neonatal Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-15     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  230-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Bronchopulmonary Dysplasia / metabolism
Disease Models, Animal
Infant, Newborn
Infant, Premature / metabolism*
Lung Injury / metabolism
Oxygen / administration & dosage*,  adverse effects
Oxygen Inhalation Therapy / adverse effects,  methods*
Grant Support
Reg. No./Substance:
0/Adrenal Cortex Hormones; 7782-44-7/Oxygen

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