Document Detail

Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring.
MedLine Citation:
PMID:  15920504     Owner:  NLM     Status:  MEDLINE    
In a series of studies on the long-term consequences of neonatal rearing, we compared hypothalamic and extrahypothalamic central corticotropin-releasing factor (CRF) systems in male rats reared under conditions of animal facility rearing, nonhandling (HMS0), handling with brief maternal separation for 15 min (HMS15), or handling with moderate maternal separation for 180 min (HMS180) daily from postnatal days 2-14. CRF-like immunoreactivity (CRFir) was elevated in lumbar cerebrospinal fluid of adult HMS180 and HMS0 rats relative to the other groups. In the paraventricular nucleus, central nucleus of the amygdala, bed nucleus of the stria terminalis, and locus coeruleus, CRFir and CRF mRNA levels were significantly elevated in HMS0 and HMS180 rats. Neonatal maternal separation was associated with regionally specific alterations in CRF receptor type 1 (CRF1) mRNA density in HMS180 rats. No rearing-associated differences in CRF2alpha binding were apparent in either the lateral septum or the ventromedial hypothalamus. These findings indicate that early rearing conditions can permanently alter the developmental set-point of central CRF systems, and potentially influence the expression of behavioral and endocrine responses to stress throughout life, thereby providing a possible neurobiological substrate for the relationship between early life events and increased vulnerability for hypothalamic-pituitary-adrenal axis and coping skill alterations and the frequency of mood disorders in patients with a history of such experiences.
Paul M Plotsky; K V Thrivikraman; Charles B Nemeroff; Christian Caldji; Shakti Sharma; Michael J Meaney
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  30     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-01-24     Revised Date:  2011-05-18    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2192-204     Citation Subset:  IM    
Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA.
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MeSH Terms
Adrenocorticotropic Hormone / cerebrospinal fluid,  metabolism
Animals, Newborn / physiology*
Behavior, Animal / physiology
Corticosterone / cerebrospinal fluid,  metabolism
Corticotropin-Releasing Hormone / metabolism,  physiology*
Hypothalamus / physiology
Image Processing, Computer-Assisted
In Situ Hybridization
Physical Stimulation
RNA, Messenger / biosynthesis,  genetics
Rats, Long-Evans
Receptors, Corticotropin-Releasing Hormone / biosynthesis,  genetics
Startle Reaction
Stress, Psychological / physiopathology
Grant Support
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Corticotropin-Releasing Hormone; 50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone; 9015-71-8/Corticotropin-Releasing Hormone

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