| Long-term consequences of fetal and neonatal nicotine exposure: a critical review. | |
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MedLine Citation:
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PMID: 20363831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal, and developmental complications, as well as an increased risk of adverse health consequences in the adult offspring. Nicotine replacement therapy (NRT) has been developed as a pharmacotherapy for smoking cessation and is considered to be a safer alternative for women to smoking during pregnancy. The safety of NRT use during pregnancy has been evaluated in a limited number of short-term human trials, but there is currently no information on the long-term effects of developmental nicotine exposure in humans. However, animal studies suggest that nicotine alone may be a key chemical responsible for many of the long-term effects associated with maternal cigarette smoking on the offspring, such as impaired fertility, type 2 diabetes, obesity, hypertension, neurobehavioral defects, and respiratory dysfunction. This review will examine the long-term effects of fetal and neonatal nicotine exposure on postnatal health. |
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Authors:
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Jennifer E Bruin; Hertzel C Gerstein; Alison C Holloway |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-04-02 |
Journal Detail:
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Title: Toxicological sciences : an official journal of the Society of Toxicology Volume: 116 ISSN: 1096-0929 ISO Abbreviation: Toxicol. Sci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9805461 Medline TA: Toxicol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 364-74 Citation Subset: IM |
Affiliation:
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Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Diabetes Mellitus, Type 2 / chemically induced Female Fertility / drug effects Fetal Hypoxia / metabolism Fetus / drug effects* Humans Hypertension / chemically induced Lung / drug effects, embryology Neoplasms / chemically induced Nicotine / toxicity* Obesity / chemically induced Pregnancy Prenatal Exposure Delayed Effects* Smoking Cessation |
| Grant Support | |
ID/Acronym/Agency:
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86474//Canadian Institutes of Health Research; MOPs 178140//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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