Document Detail

Long-term complications of preeclampsia.
MedLine Citation:
PMID:  21266269     Owner:  NLM     Status:  MEDLINE    
Preeclampsia is a multi-organ syndrome of pregnancy, defined by the new onset of hypertension and proteinuria after 20 weeks' gestation. This working definition ignores the variable multi-organ involvement of a syndrome that can include seizures in the absence of hypertension, or fulminating hepatic necrosis in the absence of proteinuria. These disparate clinical features are akin to an accelerated metabolic syndrome with widespread maternal endothelial dysfunction in the presence of a relatively underperfused placenta. Delivery of the placenta remains the only cure, but years after a pregnancy complicated by preeclampsia, women are at increased risk of chronic hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular disease, kidney disease, thromboembolism, hypothyroidism, and even impaired memory. This article describes how pregnancy propels vulnerable women toward preeclampsia and how a brief, usually single, episode of this acute pregnancy syndrome defines those vulnerable to chronic disease in later life.
David Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in nephrology     Volume:  31     ISSN:  1558-4488     ISO Abbreviation:  Semin. Nephrol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-26     Completed Date:  2011-06-08     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8110298     Medline TA:  Semin Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Maternal Medicine, Institute for Women's Health, University College London Hospital, 74 Huntley Street, London, United Kingdom.
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MeSH Terms
Cardiovascular Diseases / complications*
Dyslipidemias / complications
Fetal Growth Retardation
Kidney Diseases / complications
Mental Health
Metabolic Syndrome X / complications
Neoplasms / complications
Obstetric Labor, Premature
Pre-Eclampsia / pathology,  physiopathology*
Thyroid Diseases / complications
Venous Thromboembolism / complications
Grant Support
//Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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