| Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. | |
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MedLine Citation:
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PMID: 15169957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pathogenic mechanisms by which physical exercise influences atherosclerotic lesion formation remain poorly understood. Because vigorous physical training increases oxidative stress, this study tested the hypothesis that graduated and moderate physical exercise together with metabolic intervention (l-arginine and antioxidants) may contribute to increased vascular protection. Exercise training in mice was induced by graduated swimming. In hypercholesterolemic male mice on an atherogenic high-cholesterol diet, graduated and moderate exercise lowered plasma cholesterol and decreased atherosclerotic lesions compared with sedentary control mice. Antioxidants (1.0% vitamin E added to the chow and 0.05% vitamin C added to the drinking water) and l-arginine (6% in drinking water) supplementation to exercising hypercholesterolemic mice further and synergistically reduced atherosclerosis compared with untreated exercised mice. Arterial oxidation-specific epitopes and systemic oxidative stress were reduced by metabolic intervention. Graduated chronic exercise elicited an increase in production of nitric oxide through increased endothelial nitric oxide synthase expression and ameliorated scavenger activities. Thus, metabolic intervention with l-arginine and antioxidants together with graduated and moderate exercise training reduce atherosclerotic lesion formation. |
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Authors:
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Claudio Napoli; Sharon Williams-Ignarro; Filomena De Nigris; Lilach O Lerman; Loredana Rossi; Carmen Guarino; Gelsomina Mansueto; Francesco Di Tuoro; Orlando Pignalosa; Gaetano De Rosa; Vincenzo Sica; Louis J Ignarro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2004-05-28 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 101 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-09 Completed Date: 2004-08-17 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 8797-802 Citation Subset: IM |
Affiliation:
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Department of General Pathology, Medicine, Clinical Pathology, and Human Pathology, University of Naples, 80131 Naples, Italy. claunap@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / therapeutic use* Arginine / therapeutic use Arteriosclerosis / etiology, metabolism, prevention & control* Ascorbic Acid / therapeutic use Diet, Atherogenic Hyperlipoproteinemia Type II / complications*, metabolism, therapy* Male Mice Mice, Knockout Nitric Oxide Synthase / metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Oxidative Stress Physical Conditioning, Animal* Receptors, LDL / deficiency, genetics Vitamin E / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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HL-58433/HL/NHLBI NIH HHS; HL-66999/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Receptors, LDL; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos2 protein, mouse; EC 1.14.13.39/Nos3 protein, mouse |
| Comments/Corrections | |
Erratum In:
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Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18262 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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