Document Detail

Long-term cognitive functions in neonatal short bowel syndrome patients.
MedLine Citation:
PMID:  18437651     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the study was to evaluate the long-term effects of neonatal short bowel syndrome on cognitive functions during development. SUBJECTS AND METHODS: Nine patients diagnosed with short bowel syndrome during the neonatal period were enrolled in this study. Their medical records were reviewed; anthropometric measurements and blood tests were assayed; IQ tests (the Chinese versions of WAIS-R, WPPSI-R and WISC-R) were performed depending on their age, and a BSID assessment was carried out in those patients less than 4 years old. RESULTS: Eight of 9 patients were followed up except for one patient who died in a car accident at the age of three. All patients had been weaned off parenteral nutrition for more than 2 years. The average residual small bowel length was 58.1 cm (range 35-70 cm), and the mean parenteral nutrition (PN) duration was 73.1 days (43-147 days). The mean duration of the period without PN was 7.4 years (range 2.1-17.1 years). Weight, height and BMI for age were normal in 7 children except for 1 child, who was overweight. Hemoglobin and albumin concentrations were normal in all 8 patients. Evaluation of cognitive development showed normal results for all 8 patients while a verbal/performance discrepancy was found in 2. CONCLUSION: Patients with neonatal SBS who were weaned off PN for more than 2 years were found to have normal growth and cognitive development during this long-term follow-up. There was no evidence for a strong correlation between SBS and nutritional/cognition disorder. Longer term and controlled studies with a larger sample size are warranted.
J Huang; W Cai; Q Tang; Y Feng; Y Tao; Y Wang; J Wu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie     Volume:  18     ISSN:  0939-7248     ISO Abbreviation:  Eur J Pediatr Surg     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-25     Completed Date:  2008-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105263     Medline TA:  Eur J Pediatr Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  89-92     Citation Subset:  IM    
Clinical Nutrition Center, Shanghai Jiao Tong University, School of Medicine, Xin Hua Hospital, Shanghai, China.
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MeSH Terms
Child, Preschool
Cognition Disorders / diagnosis,  etiology*
Digestive System Abnormalities / complications*,  surgery
Digestive System Surgical Procedures / adverse effects
Follow-Up Studies
Intestine, Small / surgery
Nutritional Status
Parenteral Nutrition
Severity of Illness Index
Short Bowel Syndrome / complications*,  surgery
Treatment Outcome
Wechsler Scales

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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