Document Detail

Long-term clinical and neurophysiological follow-up of patients with peripheral, neuropathy associated with benign monoclonal gammopathy.
MedLine Citation:
PMID:  10639606     Owner:  NLM     Status:  MEDLINE    
The incidence of hematological malignancy in patients with monoclonal gammopathy of undetermined significance (MGUS) has been assessed as 17% to 25%. To ascertain whether this is true of neuropathy associated with MGUS, a long-term (5-42 years) retrospective clinical and neurophysiological follow-up was conducted in 50 cases (immunoglobulin M [IgM], n = 38; IgG, n = 11; IgA, n = 1). Only three patients developed hematological malignancy. Of 25 survivors with IgM paraproteinemia, 7 had myelin-associated glycoprotein antibodies with typical clinical features. Evoked distal muscle amplitudes were significantly smaller than for the other paraprotein classes. Preferential distal demyelination manifested by relative prolongation of distal motor latency was not apparent in the cases of long duration. Two patients with IgM antidisialosyl antibodies and cold agglutinating activity had a large fiber neuropathy with intermittent oculofacial involvement. Both responded to intravenous immunoglobulin. Findings in the remaining patients were varied. Recognition of IgM subgroups is important both for prognosis and possible response to treatment.
S Ponsford; H Willison; J Veitch; R Morris; P K Thomas
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Muscle & nerve     Volume:  23     ISSN:  0148-639X     ISO Abbreviation:  Muscle Nerve     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7803146     Medline TA:  Muscle Nerve     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-74     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Department of Clinical Neurophysiology, Walsgrave Hospital, Clifford Bridge Road, Coventry, CV2 2DX, UK.
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MeSH Terms
Aged, 80 and over
Follow-Up Studies
Hematologic Neoplasms / complications
Immunoglobulin G / immunology
Immunoglobulin M / immunology
Middle Aged
Monoclonal Gammopathy of Undetermined Significance / complications*
Neural Conduction / physiology
Paraproteinemias / immunology
Peripheral Nervous System Diseases / complications*,  physiopathology,  therapy*
Retrospective Studies
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M
Comment In:
Muscle Nerve. 2000 Feb;23(2):150-2   [PMID:  10639604 ]

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