| Long-term clinical follow-up after sirolimus-eluting stent versus bare metal stent implantation in patients with acute coronary syndrome. | |
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MedLine Citation:
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PMID: 19490360 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Drug-eluting stents have been shown to reduce the incidence of restenosis and target vessel revascularization (TVR) compared with bare metal stents (BMSs); however, the long-term efficacy of sirolimus-eluting stent (SES) implantation in patients with acute coronary syndrome (ACS) has not been well established. We have investigated the long-term clinical outcome of SES in patients with ACS. METHODS: Consecutive 245 patients with ACS treated by primary stenting within 24 hours after onset were enrolled. There were 128 patients treated with SES and 117 patients were treated with BMS. We evaluated the incidence of major cardiac events (MACE; total death, nonfatal myocardial infarction, TVR) at 3 years, comparing with 8-month clinical outcome. RESULTS: Eight-month clinical follow-up shows a significantly lower incidence of TVR in the SES group, 3.1% in the SES group versus 9.4% in the BMS group (P = 0.04). At 3-year clinical follow-up, there was no significant difference in the rate of TVR between the two groups, 8.4% versus 12.4% (P = 0.37). Cumulative incidence of total MACE was 9.2% in the SES group compared with 15.9% in the BMS group (P = 0.18). Only one case of stent thrombosis was observed in the SES (late thrombosis), while two cases of stent thrombosis occurred in the BMS group (late and very late thrombosis; P = 0.55). CONCLUSION: SES implantation in patients with ACS is associated with favorable long-term clinical outcome with no excess of late stent thrombosis. Further long-term clinical follow-up will be warranted to confirm the safety and efficacy of SES. |
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Authors:
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Manabu Ogita; Tomohiro Nakamura; Naoki Fujiwara; Kenichi Sakakura; Hiroshi Funayama; Yoshitaka Sugawara; Norifumi Kubo; Junya Ako; Shinichi Momomura |
Publication Detail:
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Type: Journal Article Date: 2009-03-13 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 22 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-07-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 216-21 Citation Subset: IM |
Affiliation:
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Cardiovascular Division, Saitama Medical Center, Jichi Medical University, Saitama, Japan. m-ogita@sa2.so-net.ne.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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