Document Detail

Long-term circulatory consequences of perinatal iron deficiency in male Wistar rats.
MedLine Citation:
PMID:  17967999     Owner:  NLM     Status:  MEDLINE    
Perinatal iron deficiency (PID) has been reported to induce developmental abnormalities, including cardiovascular complications in rats. These complications are believed to be "programmed" by an aberrant perinatal environment because the changes persist long after the insult is corrected (ie, despite subsequent iron replenishment). Little is known about the mechanisms by which PID affects blood pressure in the offspring, although the kidney is likely to play a central role. The objective of this study was to investigate the circulatory complications of PID and the putative role of the kidney involved therein. Before and throughout gestation, female Wistar rats were fed either a low-iron diet (3 ppm/10 ppm Fe) or an iron-enriched diet (225 ppm Fe). After giving birth, all of the dams were placed on a standard grain-based diet. At 24 hours postpartum, hematocrits and hemoglobin levels from offspring of iron-deficient mothers were 60% and 59% of control values, respectively. Adult PID animals had greater mean arterial pressures (110 versus 106 mm Hg) and systolic blood pressures (129 versus124 mm Hg) than controls, as assessed by radiotelemetry. The relationship between renal arterial pressure and renal interstitial hydrostatic pressure, assessed in anesthetized rats, was blunted by 41% in the PID group compared with controls. In addition, arterial pressure changes were significantly greater in response to altered sodium in the PID animals compared with controls. These data confirm that PID adversely affects blood pressure control, which seems to be mediated, at least in part, by altered intrarenal hemodynamic properties.
Stephane L Bourque; Marina Komolova; Kanji Nakatsu; Michael A Adams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-29
Journal Detail:
Title:  Hypertension     Volume:  51     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-01-10     Revised Date:  2008-05-07    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-9     Citation Subset:  IM    
Department of Pharmacology and Toxicology, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada K7L 3N6.
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MeSH Terms
Blood Circulation / drug effects,  physiology
Blood Pressure / drug effects,  physiology*
Dose-Response Relationship, Drug
Hypertension / etiology,  physiopathology
Iron / deficiency*,  physiology
Kidney / blood supply,  drug effects
Prenatal Exposure Delayed Effects / metabolism,  physiopathology*
Renal Artery / physiopathology
Sodium, Dietary / pharmacology
Reg. No./Substance:
0/Sodium, Dietary; 7439-89-6/Iron
Erratum In:
Hypertension. 2008 May;51(5):e44

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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